To evaluate CXCL10 and CCL2 in patients with hepatitis C virus chronic infection in presence/absence of autoimmune thyroiditis (AT). CXCL10 was significantly higher in: (1) patients with AT than controls without AT (control 1) (P < 0.001; ANOVA); (2) patients with hepatitis C infection than control 1 and patients with AT (P < 0.001); (3) patients with hepatitis C virus chronic infection and AT (HCV+AT) than control 1 and patients with AT (P < 0.001) and hepatitis C (P = 0.004). By defining a high CXCL10 level as a value >218 pg/mL, 2% of control 1, 14% of patients with AT, 68% of patients with hepatitis C infection, 81% of HCV+AT had high CXCL10 (P < 0.0001; chi-square). CCL2 was similar in control 1 and patients with AT. CCL2 was significantly higher in: (1) patients with hepatitis C infection than control 1 (P = 0.04; ANOVA); (2) HCV+AT than patients with AT (P = 0.03) and control 1 (P = 0.02); no difference was observed between HCV with or without AT. Our study demonstrates: (1) higher circulating CXCL10 and CCL2 in patients with hepatitis C virus chronic infection than in controls; (2) higher CXCL10 in HCV+AT than in patients with hepatitis C infection, suggesting a stronger Th1 immune response in these patients.

CXCL10 and CCL2 Chemokine Serum Levels in Patients With Hepatitis C Associated With Autoimmune Thyroiditis / Antonelli, A; Ferri, Clodoveo; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Pampana, A; Panicucci, E; Carpi, A; Nicolini, A; Ferrannini, E.. - In: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. - ISSN 1079-9907. - STAMPA. - 29:6(2009), pp. 345-351. [10.1089/jir.2008.0090]

CXCL10 and CCL2 Chemokine Serum Levels in Patients With Hepatitis C Associated With Autoimmune Thyroiditis

FERRI, Clodoveo;FERRARI, Silvia Martina;
2009

Abstract

To evaluate CXCL10 and CCL2 in patients with hepatitis C virus chronic infection in presence/absence of autoimmune thyroiditis (AT). CXCL10 was significantly higher in: (1) patients with AT than controls without AT (control 1) (P < 0.001; ANOVA); (2) patients with hepatitis C infection than control 1 and patients with AT (P < 0.001); (3) patients with hepatitis C virus chronic infection and AT (HCV+AT) than control 1 and patients with AT (P < 0.001) and hepatitis C (P = 0.004). By defining a high CXCL10 level as a value >218 pg/mL, 2% of control 1, 14% of patients with AT, 68% of patients with hepatitis C infection, 81% of HCV+AT had high CXCL10 (P < 0.0001; chi-square). CCL2 was similar in control 1 and patients with AT. CCL2 was significantly higher in: (1) patients with hepatitis C infection than control 1 (P = 0.04; ANOVA); (2) HCV+AT than patients with AT (P = 0.03) and control 1 (P = 0.02); no difference was observed between HCV with or without AT. Our study demonstrates: (1) higher circulating CXCL10 and CCL2 in patients with hepatitis C virus chronic infection than in controls; (2) higher CXCL10 in HCV+AT than in patients with hepatitis C infection, suggesting a stronger Th1 immune response in these patients.
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CXCL10 and CCL2 Chemokine Serum Levels in Patients With Hepatitis C Associated With Autoimmune Thyroiditis / Antonelli, A; Ferri, Clodoveo; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Pampana, A; Panicucci, E; Carpi, A; Nicolini, A; Ferrannini, E.. - In: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. - ISSN 1079-9907. - STAMPA. - 29:6(2009), pp. 345-351. [10.1089/jir.2008.0090]
Antonelli, A; Ferri, Clodoveo; Fallahi, P; Ferrari, Silvia Martina; Frascerra, S; Pampana, A; Panicucci, E; Carpi, A; Nicolini, A; Ferrannini, E.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/646419
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