Phenylbutazone was loaded on colloidal silicon dioxide in various proportions either by organic solvent evaporation and by grinding. Besides reducing the drug crystallinity, these preparation methods turned completely or partly the form IV of the drug into form III.
Study of solid phenylbutazone dispersions on colloidal silica / Forni, Flavio; Iannuccelli, Valentina; Vandelli, Maria Angela; Cameroni, Riccardo. - In: STP PHARMA. - ISSN 0758-6922. - STAMPA. - 3:(1987), pp. 758-762.