The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.

The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres / Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo. - In: JOURNAL DE PHARMACIE DE BELGIQUE. - ISSN 0047-2166. - STAMPA. - 46:(1991), pp. 381-388.

The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres

VANDELLI, Maria Angela;FORNI, Flavio;IANNUCCELLI, Valentina;CAMERONI, Riccardo
1991

Abstract

The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
1991
46
381
388
The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres / Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo. - In: JOURNAL DE PHARMACIE DE BELGIQUE. - ISSN 0047-2166. - STAMPA. - 46:(1991), pp. 381-388.
Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/646061
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