The effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres / Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo. - In: JOURNAL DE PHARMACIE DE BELGIQUE. - ISSN 0047-2166. - STAMPA. - 46:(1991), pp. 381-388.