EnglishThe effect of the concentration of a cross-linking agent (gelatin hardener) on gelatin microspheres was evaluated. A concentration increase of the gelatin hardener (formaldehyde) produced a decrease of drug loading, swelling degree and drug release rate. The cross-linking agent concentration affected also the kinetics of water absorption and drug release. This paper suggests a decreasing significance of the diffusion-type mechanism of drug release as the concentration of the cross-linking agent increased.
The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres / Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo. - In: JOURNAL DE PHARMACIE DE BELGIQUE. - ISSN 0047-2166. - STAMPA. - 46(1991), pp. 381-388.
| Data di pubblicazione: | 1991 |
| Titolo: | The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres |
| Autore/i: | Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 46 |
| Pagina iniziale: | 381 |
| Pagina finale: | 388 |
| Codice identificativo Scopus: | 2-s2.0-0026327071 |
| Codice identificativo Pubmed: | 1783972 |
| Citazione: | The concentration of the cross-linking agent as a tool for the control of release and swelling properties of gelatin microspheres / Vandelli, Maria Angela; Forni, Flavio; Iannuccelli, Valentina; Cameroni, Riccardo. - In: JOURNAL DE PHARMACIE DE BELGIQUE. - ISSN 0047-2166. - STAMPA. - 46(1991), pp. 381-388. |
| Tipologia | Articolo su rivista |
File in questo prodotto:
http://hdl.handle.net/11380/646061
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2021