Abstract Objective. To demonstrate the efficacy and safety of long-term therapy with oxycodone in severe pain of scleroderma skin ulcers. Design. Open study. Setting and Patients. Twenty-nine consecutive patients, referred to our Rheumatology Unit during 2006, affected by systemic sclerosis complicated by painful long-standing skin ulcers entered in the study. In all cases, pain was classified as severe according to World Health Organization guidelines, and oxycodone chloridrate (Oxycontin(R); Mundipharma Pharmaceuticals, Milan, Italy) was administrated at the dosage of 10-20 mg twice daily for a mean period of 7.9 +/- 3.2 standard deviation months. Outcome Measures. To evaluate the efficacy and safety of opioid therapy, the following parameters were recorded at standard time intervals: visual analog scale (VAS) pain, Pittsburgh sleep quality index (PSQI), hours of sleep per night, Health Assessment Questionnaire-Disability index, analgesics use (rescue therapy), side effects, vital signs, routine laboratory assessment. Results. After 1 month of therapy, all patients experienced relief of pain (VAS decreased from 93.8 +/- 8.72 to 56.7 +/- 10.4, P < 0.0001), and better quality of sleep (total hours of sleep increased from 3.68 +/- 1.28 to 5.27 +/- 0.75, P < 0.0001; PSQI decreased from 9.72 +/- 3.95 to 3.37 +/- 1.04, P < 0.0001). These parameters further improved after 3 months of therapy and remained stable during the follow-up; moreover, an increase of daily dosage of oxycodone was never required. The observed side effects were always transient and mild; only constipation, when present, was persistent. Conclusion. Oxycodone showed to be effective and safe in the treatment of pain due to severe scleroderma skin ulcers; contemporarily, it markedly improved the patient's compliance to local wound care procedures.

Oxycodone in the Long-Term Treatment of Chronic Pain Related to Scleroderma Skin Ulcers / D., Giuggioli; Manfredi, Andreina Teresa; Colaci, Michele; Ferri, Clodoveo. - In: PAIN MEDICINE. - ISSN 1526-2375. - STAMPA. - 11(2010), pp. 1500-1503. [10.1111/j.1526-4637.2010.00849.x]

Oxycodone in the Long-Term Treatment of Chronic Pain Related to Scleroderma Skin Ulcers.

D. Giuggioli;MANFREDI, Andreina Teresa;COLACI, Michele;FERRI, Clodoveo
2010

Abstract

Abstract Objective. To demonstrate the efficacy and safety of long-term therapy with oxycodone in severe pain of scleroderma skin ulcers. Design. Open study. Setting and Patients. Twenty-nine consecutive patients, referred to our Rheumatology Unit during 2006, affected by systemic sclerosis complicated by painful long-standing skin ulcers entered in the study. In all cases, pain was classified as severe according to World Health Organization guidelines, and oxycodone chloridrate (Oxycontin(R); Mundipharma Pharmaceuticals, Milan, Italy) was administrated at the dosage of 10-20 mg twice daily for a mean period of 7.9 +/- 3.2 standard deviation months. Outcome Measures. To evaluate the efficacy and safety of opioid therapy, the following parameters were recorded at standard time intervals: visual analog scale (VAS) pain, Pittsburgh sleep quality index (PSQI), hours of sleep per night, Health Assessment Questionnaire-Disability index, analgesics use (rescue therapy), side effects, vital signs, routine laboratory assessment. Results. After 1 month of therapy, all patients experienced relief of pain (VAS decreased from 93.8 +/- 8.72 to 56.7 +/- 10.4, P < 0.0001), and better quality of sleep (total hours of sleep increased from 3.68 +/- 1.28 to 5.27 +/- 0.75, P < 0.0001; PSQI decreased from 9.72 +/- 3.95 to 3.37 +/- 1.04, P < 0.0001). These parameters further improved after 3 months of therapy and remained stable during the follow-up; moreover, an increase of daily dosage of oxycodone was never required. The observed side effects were always transient and mild; only constipation, when present, was persistent. Conclusion. Oxycodone showed to be effective and safe in the treatment of pain due to severe scleroderma skin ulcers; contemporarily, it markedly improved the patient's compliance to local wound care procedures.
11
1500
1503
Oxycodone in the Long-Term Treatment of Chronic Pain Related to Scleroderma Skin Ulcers / D., Giuggioli; Manfredi, Andreina Teresa; Colaci, Michele; Ferri, Clodoveo. - In: PAIN MEDICINE. - ISSN 1526-2375. - STAMPA. - 11(2010), pp. 1500-1503. [10.1111/j.1526-4637.2010.00849.x]
D., Giuggioli; Manfredi, Andreina Teresa; Colaci, Michele; Ferri, Clodoveo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/645819
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