NIR-labeled nanoparticles engineered for brain targeting: in vivo optical imaging application and fluorescent microscopy evidences.

Tosi, Giovanni; Bondioli, Lucia; Ruozi, Barbara; Badiali, Luca; Severini, Gm; Biffi, S.; De Vita, A.; Bortot, B.; Dolcetta, D.; Forni, Flavio; Vandelli, Maria Angela

doi:10.1007/s00702-010-0497-1

The presence of the blood–brain barrier (BBB)makes extremely difficult to develop efficacious strategiesfor targeting contrast agents and delivering drugs inside theCentral Nervous System (CNS). To overcome this drawback,several kinds of CNS-targeted nanoparticles (NPs)have been developed. In particular, we proposed polylactide-co-glycolide (PLGA) NPs engineered with a similopioidglycopeptide (g7), which have already proved to bea promising tool for achieving a successful brain targetingafter i.v. administration in rats. In order to obtain CNStargetedNPs to use for in vivo imaging, we synthesizedand administrated in mice PLGA NPs with double coverage:near-infrared (NIR) probe (DY-675) and g7. Theoptical imaging clearly showed a brain localization of thesenovel NPs. Thus, a novel kind of NIR-labeled NPs wereobtained, providing a new, in vivo detectable nanotechnologytool. Besides, the confocal and fluorescencemicroscopy evidences allowed to further confirm the abilityof g7 to promote not only the rat, but also the mouseBBB crossing.

NIR-labeled nanoparticles engineered for brain targeting: in vivo optical imaging application and fluorescent microscopy evidences / Tosi, Giovanni; Bondioli, Lucia; Ruozi, Barbara; Badiali, Luca; Gm, Severini; S., Biffi; A., De Vita; B., Bortot; D., Dolcetta; Forni, Flavio; Vandelli, Maria Angela. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 118(2011), pp. 145-153.

Data di pubblicazione:	2011
Titolo:	NIR-labeled nanoparticles engineered for brain targeting: in vivo optical imaging application and fluorescent microscopy evidences.
Autore/i:	Tosi, Giovanni; Bondioli, Lucia; Ruozi, Barbara; Badiali, Luca; Gm, Severini; S., Biffi; A., De Vita; B., Bortot; D., Dolcetta; Forni, Flavio; Vandelli, Maria Angela
Autore/i UNIMORE:	TOSI, Giovanni BONDIOLI, Lucia RUOZI, Barbara BADIALI, Luca GM Severini S. Biffi A. De Vita B. Bortot D. Dolcetta FORNI, Flavio VANDELLI, Maria Angela mostra contributor esterni nascondi contributor esterni
Digital Object Identifier (DOI):	http://dx.doi.org/10.1007/s00702-010-0497-1
Rivista:	JOURNAL OF NEURAL TRANSMISSION
Volume:	118
Pagina iniziale:	145
Pagina finale:	153
Codice identificativo ISI:	WOS:000286605700012
Codice identificativo Scopus:	2-s2.0-79951676874
Codice identificativo Pubmed:	20931242
Citazione:	NIR-labeled nanoparticles engineered for brain targeting: in vivo optical imaging application and fluorescent microscopy evidences / Tosi, Giovanni; Bondioli, Lucia; Ruozi, Barbara; Badiali, Luca; Gm, Severini; S., Biffi; A., De Vita; B., Bortot; D., Dolcetta; Forni, Flavio; Vandelli, Maria Angela. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 118(2011), pp. 145-153.
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