High amounts of glutamate are found in the brains of people with multiple sclerosis, an inflammatory disease marked by progressive demyelination. Glutamate might affect neuroinflammation via effects on immune cells. Knockout mice lacking metabotropic glutamate receptor-4 (mGluR4) were markedly vulnerable to experimental autoimmune encephalomyelitis (EAE, a mouse model of multiple sclerosis) and developed responses dominated by interleukin-17-producing T helper (T(H)17) cells. In dendritic cells (DCs) from those mice, defective mGluR4 signaling-which would normally decrease intracellular cAMP formation-biased T(H) cell commitment to the T(H)17 phenotype. In wild-type mice, mGluR4 was constitutively expressed in all peripheral DCs, and this expression increased after cell activation. Treatment of wild-type mice with a selective mGluR4 enhancer increased EAE resistance via regulatory T (T(reg)) cells. The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation / Fallarino, F; Volpi, C; Fazio, F; Notartomaso, S; Vacca, C; Busceti, C; Bicciato, Silvio; Battaglia, G; Bruno, V; Puccetti, P; Fioretti, Mc; Nicoletti, F; Grohmann, U; Di Marco, R.. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 16(8)(2010), pp. 897-902. [10.1038/nm.2183]

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

BICCIATO, Silvio;
2010

Abstract

High amounts of glutamate are found in the brains of people with multiple sclerosis, an inflammatory disease marked by progressive demyelination. Glutamate might affect neuroinflammation via effects on immune cells. Knockout mice lacking metabotropic glutamate receptor-4 (mGluR4) were markedly vulnerable to experimental autoimmune encephalomyelitis (EAE, a mouse model of multiple sclerosis) and developed responses dominated by interleukin-17-producing T helper (T(H)17) cells. In dendritic cells (DCs) from those mice, defective mGluR4 signaling-which would normally decrease intracellular cAMP formation-biased T(H) cell commitment to the T(H)17 phenotype. In wild-type mice, mGluR4 was constitutively expressed in all peripheral DCs, and this expression increased after cell activation. Treatment of wild-type mice with a selective mGluR4 enhancer increased EAE resistance via regulatory T (T(reg)) cells. The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis
16(8)
897
902
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation / Fallarino, F; Volpi, C; Fazio, F; Notartomaso, S; Vacca, C; Busceti, C; Bicciato, Silvio; Battaglia, G; Bruno, V; Puccetti, P; Fioretti, Mc; Nicoletti, F; Grohmann, U; Di Marco, R.. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 16(8)(2010), pp. 897-902. [10.1038/nm.2183]
Fallarino, F; Volpi, C; Fazio, F; Notartomaso, S; Vacca, C; Busceti, C; Bicciato, Silvio; Battaglia, G; Bruno, V; Puccetti, P; Fioretti, Mc; Nicoletti, F; Grohmann, U; Di Marco, R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/645137
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