Soft-tissue sarcoma is a rare neoplasia of the connective tissue with unknown etiology. Heavy metals and dioxins, which are also emitted by municipal solid waste incinerators, are among the environmental factors suspected to play a role in its etiology.We assessed the possible relation between long-term exposure to emissions of a municipal solid waste incinerator and risk of soft-tissue sarcoma in the Italian municipality of Reggio Emilia through a population-based case-control study. We identified 50 cases of newly-diagnosed sarcomas from 2001 to 2008, and we randomly selected 4 population controls for each case, matched for sex and age. We identified and geocoded residential history of study subjects, and we identified two areas of intermediate and high exposure to emissions of the city solid waste incinerator. All this information was added to a Geographical Information System database, to assess exposure status of study subjects and to calculate the associated relative risk (RR) of soft-tissue sarcoma with its 95% confidence interval (CI) in a conditional logistic regression model. Three cases of soft tissue sarcoma occurred among previously exposed subjects. Residence in one of the two exposed areas was associated with a RR of 0.52 (CI 0.12-2.37) at disease diagnosis and with a RR of 1.10 (CI 0.28-4.35) 20 years before, after adjusting for educational attainment. When we limited the analysis to highly exposed subjects, we found a RR relative risk of 1.93 (CI 0.32-11.71) at diagnosis and of 3.70 (CI 0.72-18.97) 20 years before. No dose-response relation between exposure status and disease risk emerged.Overall, risk of soft-tissue sarcoma was increased among subjects with high exposure to incinerator emissions, but risk estimates were statistically very unstable and no evidence of dose-response relation emerged. Larger studies are required to confirm a relation between emissions from waste incineration and incidence of soft-tissue sarcoma.
INCINERATION OF MUNICIPAL SOLID WASTE AND RISK OF SOFT-TISSUE SARCOMA: A CASE-CONTROL STUDY / N., Borciani; R., Rodolfi; G., Carlinfante; Malagoli, Carlotta; Vinceti, Marco; Bergomi, Margherita. - In: EPIDEMIOLOGY. - ISSN 1044-3983. - STAMPA. - 22:(2010), pp. S294-S294. (Intervento presentato al convegno 2010 Joint Conference of International Society of Exposure Science & International Society for Environmental Epidemiology tenutosi a Seoul, Korea nel 28 August - 1 September 2010) [10.1097/01.ede.0000392604.46875.9e].
INCINERATION OF MUNICIPAL SOLID WASTE AND RISK OF SOFT-TISSUE SARCOMA: A CASE-CONTROL STUDY
MALAGOLI, Carlotta;VINCETI, Marco;BERGOMI, Margherita
2010
Abstract
Soft-tissue sarcoma is a rare neoplasia of the connective tissue with unknown etiology. Heavy metals and dioxins, which are also emitted by municipal solid waste incinerators, are among the environmental factors suspected to play a role in its etiology.We assessed the possible relation between long-term exposure to emissions of a municipal solid waste incinerator and risk of soft-tissue sarcoma in the Italian municipality of Reggio Emilia through a population-based case-control study. We identified 50 cases of newly-diagnosed sarcomas from 2001 to 2008, and we randomly selected 4 population controls for each case, matched for sex and age. We identified and geocoded residential history of study subjects, and we identified two areas of intermediate and high exposure to emissions of the city solid waste incinerator. All this information was added to a Geographical Information System database, to assess exposure status of study subjects and to calculate the associated relative risk (RR) of soft-tissue sarcoma with its 95% confidence interval (CI) in a conditional logistic regression model. Three cases of soft tissue sarcoma occurred among previously exposed subjects. Residence in one of the two exposed areas was associated with a RR of 0.52 (CI 0.12-2.37) at disease diagnosis and with a RR of 1.10 (CI 0.28-4.35) 20 years before, after adjusting for educational attainment. When we limited the analysis to highly exposed subjects, we found a RR relative risk of 1.93 (CI 0.32-11.71) at diagnosis and of 3.70 (CI 0.72-18.97) 20 years before. No dose-response relation between exposure status and disease risk emerged.Overall, risk of soft-tissue sarcoma was increased among subjects with high exposure to incinerator emissions, but risk estimates were statistically very unstable and no evidence of dose-response relation emerged. Larger studies are required to confirm a relation between emissions from waste incineration and incidence of soft-tissue sarcoma.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
