Antigen stimulation may be important for splenic marginal zone lymphoma (SMZL) pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors (BCR) was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases (PDB). Sixteen SMZL (12%) showed stereotyped BCR; 7/86 (8%) SMZL sequences retrieved from PDB also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified : 1) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV- from our series); 2) "Non-Hodgkin lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; 3) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of SMZL may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma / Zibellini, S; Capello, D; Forconi, F; Marcatili, P; Rossi, D; Rattotti, S; Franceschetti, S; Sozzi, E; Cencini, E; Marasca, Roberto; Baldini, L; Tucci, A; Bertoni, F; Passamonti, F; Orlandi, E; Varettoni, M; Merli, M; Rizzi, S; Gattei, V; Tramontano, A; Paulli, M; Gaidano, G; Arcaini, L.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 95:10(2010), pp. 1792-1796. [10.3324/haematol.2010.025437]
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma.
MARASCA, Roberto;
2010
Abstract
Antigen stimulation may be important for splenic marginal zone lymphoma (SMZL) pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors (BCR) was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases (PDB). Sixteen SMZL (12%) showed stereotyped BCR; 7/86 (8%) SMZL sequences retrieved from PDB also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified : 1) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV- from our series); 2) "Non-Hodgkin lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; 3) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of SMZL may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.File | Dimensione | Formato | |
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