Antigen stimulation may be important for splenic marginal zone lymphoma (SMZL) pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors (BCR) was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases (PDB). Sixteen SMZL (12%) showed stereotyped BCR; 7/86 (8%) SMZL sequences retrieved from PDB also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified : 1) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV- from our series); 2) "Non-Hodgkin lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; 3) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of SMZL may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma / Zibellini, S; Capello, D; Forconi, F; Marcatili, P; Rossi, D; Rattotti, S; Franceschetti, S; Sozzi, E; Cencini, E; Marasca, Roberto; Baldini, L; Tucci, A; Bertoni, F; Passamonti, F; Orlandi, E; Varettoni, M; Merli, M; Rizzi, S; Gattei, V; Tramontano, A; Paulli, M; Gaidano, G; Arcaini, L.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 95:10(2010), pp. 1792-1796. [10.3324/haematol.2010.025437]

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma.

MARASCA, Roberto;
2010

Abstract

Antigen stimulation may be important for splenic marginal zone lymphoma (SMZL) pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors (BCR) was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases (PDB). Sixteen SMZL (12%) showed stereotyped BCR; 7/86 (8%) SMZL sequences retrieved from PDB also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified : 1) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV- from our series); 2) "Non-Hodgkin lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; 3) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of SMZL may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.
2010
95
10
1792
1796
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma / Zibellini, S; Capello, D; Forconi, F; Marcatili, P; Rossi, D; Rattotti, S; Franceschetti, S; Sozzi, E; Cencini, E; Marasca, Roberto; Baldini, L; Tucci, A; Bertoni, F; Passamonti, F; Orlandi, E; Varettoni, M; Merli, M; Rizzi, S; Gattei, V; Tramontano, A; Paulli, M; Gaidano, G; Arcaini, L.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 95:10(2010), pp. 1792-1796. [10.3324/haematol.2010.025437]
Zibellini, S; Capello, D; Forconi, F; Marcatili, P; Rossi, D; Rattotti, S; Franceschetti, S; Sozzi, E; Cencini, E; Marasca, Roberto; Baldini, L; Tucci, A; Bertoni, F; Passamonti, F; Orlandi, E; Varettoni, M; Merli, M; Rizzi, S; Gattei, V; Tramontano, A; Paulli, M; Gaidano, G; Arcaini, L.
File in questo prodotto:
File Dimensione Formato  
1792.full.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 882.53 kB
Formato Adobe PDF
882.53 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/644220
Citazioni
  • ???jsp.display-item.citation.pmc??? 34
  • Scopus 77
  • ???jsp.display-item.citation.isi??? 69
social impact