PURPOSE: To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries.METHODS: Four centres reported scans from 50 patients with stage II-IV HL, acquired before and after two cycles of Adriamycin/bleomycin/vinblastine/dacarbazine. A five-point scale was used to score response scans using 'normal' mediastinum and liver as reference levels. Centres read scans independently of each other. The level of agreement between centres was determined assuming (1) that uptake in sites involved at diagnosis that was higher than liver uptake represented disease (conservative reading), and (2) that uptake in sites involved at diagnosis that was higher than mediastinal uptake represented disease (sensitive reading).RESULTS: There was agreement that the response scan was 'positive' or 'negative' for lymphoma in 44 patients with a conservative reading and in 41 patients with a sensitive reading. Kappa was 0.85 (95% CI 0.74-0.96) for conservative reading and 0.79 (95% CI 0.67-0.90) for sensitive reading. Agreement was reached in 46 and 44 patients after discussion for the conservative and sensitive readings, respectively.CONCLUSION: The criteria developed for reporting in the RATHL trial are sufficiently robust to be used in a multicentre setting.

Concordance between four European centre of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma / Barrington, S. F.; Qian, W.; Somer, E. J.; Franceschetto, Antonella; Bagni, Bruno; Brun, E.; Almquist, H.; Loft, A.; Hojgaard, L.; Federico, Massimo; Gallamini, A.; Smith, P.; Johnson, P.; O'Doherty, M. J.. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7089. - ELETTRONICO. - 37:10(2010), pp. 1824-1833. [10.1007/s00259-010-1490-5]

Concordance between four European centre of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma.

FRANCESCHETTO, Antonella;BAGNI, Bruno;FEDERICO, Massimo;
2010

Abstract

PURPOSE: To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries.METHODS: Four centres reported scans from 50 patients with stage II-IV HL, acquired before and after two cycles of Adriamycin/bleomycin/vinblastine/dacarbazine. A five-point scale was used to score response scans using 'normal' mediastinum and liver as reference levels. Centres read scans independently of each other. The level of agreement between centres was determined assuming (1) that uptake in sites involved at diagnosis that was higher than liver uptake represented disease (conservative reading), and (2) that uptake in sites involved at diagnosis that was higher than mediastinal uptake represented disease (sensitive reading).RESULTS: There was agreement that the response scan was 'positive' or 'negative' for lymphoma in 44 patients with a conservative reading and in 41 patients with a sensitive reading. Kappa was 0.85 (95% CI 0.74-0.96) for conservative reading and 0.79 (95% CI 0.67-0.90) for sensitive reading. Agreement was reached in 46 and 44 patients after discussion for the conservative and sensitive readings, respectively.CONCLUSION: The criteria developed for reporting in the RATHL trial are sufficiently robust to be used in a multicentre setting.
2010
37
10
1824
1833
Concordance between four European centre of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma / Barrington, S. F.; Qian, W.; Somer, E. J.; Franceschetto, Antonella; Bagni, Bruno; Brun, E.; Almquist, H.; Loft, A.; Hojgaard, L.; Federico, Massimo; Gallamini, A.; Smith, P.; Johnson, P.; O'Doherty, M. J.. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7089. - ELETTRONICO. - 37:10(2010), pp. 1824-1833. [10.1007/s00259-010-1490-5]
Barrington, S. F.; Qian, W.; Somer, E. J.; Franceschetto, Antonella; Bagni, Bruno; Brun, E.; Almquist, H.; Loft, A.; Hojgaard, L.; Federico, Massimo; ...espandi
File in questo prodotto:
File Dimensione Formato  
Concordance between four European centre.pdf

Solo gestori archivio

Tipologia: Versione pubblicata dall'editore
Dimensione 573.47 kB
Formato Adobe PDF
573.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/642523
Citazioni
  • ???jsp.display-item.citation.pmc??? 74
  • Scopus 289
  • ???jsp.display-item.citation.isi??? 260
social impact