BACKGROUND: Appropriate treatment of acute hepatitis C is still a matter of controversy due to the lack of large controlled trials. AIM: To assess the effectiveness of interferon as treatment for acute hepatitis C by meta-analysis. METHODS: MEDLINE search (1985-2002) was supplemented with manual searches of reference lists. Studies were included if they were controlled trials comparing interferon to no treatment and if they included patients with either post-transfusion or sporadic acute hepatitis C. Twelve trials were analyzed (414 patients). The outcome assessed was the sustained virological response (SVR) rate (undetectable hepatitis C virus RNA in serum at least 6 months after cessation of therapy). RESULTS: Interferon significantly increased the SVR (risk difference 49\%; 95\% confidence interval 32.9-65\%) in comparison to no treatment. The risk difference of SVR increased from 5 to 90\% when trials were ordered by increasing interferon weekly dose. Delaying therapy by 8-12 weeks after the onset of disease does not compromise the SVR rate. CONCLUSIONS: Current evidence is sufficient to recommend interferon treatment of patients with acute hepatitis C. A later initiation of therapy yields the same likelihood of response as early treatment. A daily induction dose during the 1st month is the best option of treatment.
When and how to treat acute hepatitis C? / A., Licata; D. D., Bona; Schepis, Filippo; L., Shahied; A., Craxí; C., Cammà. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 39(2003), pp. 1056-1062.
|Data di pubblicazione:||2003|
|Titolo:||When and how to treat acute hepatitis C?|
|Autore/i:||A., Licata; D. D., Bona; Schepis, Filippo; L., Shahied; A., Craxí; C., Cammà|
|Codice identificativo ISI:||WOS:000187225300025|
|Codice identificativo Scopus:||2-s2.0-0346243740|
|Codice identificativo Pubmed:||14642626|
|Citazione:||When and how to treat acute hepatitis C? / A., Licata; D. D., Bona; Schepis, Filippo; L., Shahied; A., Craxí; C., Cammà. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 39(2003), pp. 1056-1062.|
|Tipologia||Articolo su rivista|
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