In the present study, a further investigation of the cytotoxic activity of an acetylenic constituent of Echinacea pallida roots, namely, pentadeca-(8 Z,13 Z)-dien-11-yn-2-one, was performed, revealing a concentration-dependent cytotoxicity on several human cancer cell lines, including leukemia (Jurkat and HL-60), breast carcinoma (MCF-7), and melanoma (MeWo) cells. As part of its mechanism of action, the ability of this constituent to arrest the cell cycle in the G1 phase was demonstrated on HL-60 cells. Furthermore, a stability test of the target compound over 72 h was carried out, indicating that the cytotoxic activity can be attributed mainly to the genuine, not oxidized, molecule.

Cytotoxic activity and G1 cell cycle arrest of a dienynone from Echinacea pallida / A., Chicca; B., Adinolfi; Pellati, Federica; Orlandini, Giulia; Benvenuti, Stefania; P., Nieri. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 76:(2010), pp. 444-446. [10.1055/s-0029-1186224]

Cytotoxic activity and G1 cell cycle arrest of a dienynone from Echinacea pallida

PELLATI, Federica;ORLANDINI, GIULIA;BENVENUTI, Stefania;
2010-01-01

Abstract

In the present study, a further investigation of the cytotoxic activity of an acetylenic constituent of Echinacea pallida roots, namely, pentadeca-(8 Z,13 Z)-dien-11-yn-2-one, was performed, revealing a concentration-dependent cytotoxicity on several human cancer cell lines, including leukemia (Jurkat and HL-60), breast carcinoma (MCF-7), and melanoma (MeWo) cells. As part of its mechanism of action, the ability of this constituent to arrest the cell cycle in the G1 phase was demonstrated on HL-60 cells. Furthermore, a stability test of the target compound over 72 h was carried out, indicating that the cytotoxic activity can be attributed mainly to the genuine, not oxidized, molecule.
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Cytotoxic activity and G1 cell cycle arrest of a dienynone from Echinacea pallida / A., Chicca; B., Adinolfi; Pellati, Federica; Orlandini, Giulia; Benvenuti, Stefania; P., Nieri. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 76:(2010), pp. 444-446. [10.1055/s-0029-1186224]
A., Chicca; B., Adinolfi; Pellati, Federica; Orlandini, Giulia; Benvenuti, Stefania; P., Nieri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/640513
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