BACKGROUND AND AIM:This study aims to analyse the risk of cardiovascular events in a local cohort of patients with type 2 diabetes, and to evaluate the prognostic accuracy of four algorithms used to estimate cardiovascular risk: the Framingham study, United Kingdom Prospective Diabetes Study (UKPDS), Riskard study and Progetto Cuore.METHOD AND RESULTS:We analysed clinical charts of the Diabetes Clinics of Modena for the period 1991-95. Patients in the age range of 35-65 with type 2 diabetes and no previous cardiovascular disease were eligible. The incidence of new cardiovascular disease was compared with estimated rates deriving from the different functions. A stratification was obtained in subgroups at different cardiovascular risk, allowing comparison between the algorithms. A total of 1532 patients were eligible; women presented a worse cardiovascular risk profile. An absolute 10-year rate of cardiovascular events of 14.9% was observed. Comparing patients with events with event-free subjects, we found significant differences in systolic blood pressure, age at visit, smoking, high-density lipoprotein (HDL)-cholesterol, duration of diabetes, glycosylated haemoglobin (HbA1c) and co-morbidities. Comparing the estimated risk rate according to the different functions, Italian algorithms were more consistent with observed data; however, Progetto Cuore and Riskard show underestimation of events when applied to females.CONCLUSIONS:Estimation of cardiovascular risk is dependent on the algorithm adopted and on the baseline risk of the reference cohort. Functions designed for a specific population, including risk variables peculiar for diabetes, should be adopted to increase the performance of such functions which is clearly unsatisfactory at present.
|Data di pubblicazione:||2011|
|Titolo:||Risk for cardiovascular events in an Italian population of patients with type 2 diabetes|
|Autore/i:||E. Pellegrini; M. Maurantonio; I.M. Giannico; M.S. Simonini; D. Ganazzi; L. Carulli; R. D’Amico; A. Baldini; P. Loria; M. Bertolotti; N. Carulli|
|Digital Object Identifier (DOI):||10.1016/j.numecd.2010.02.022|
|Codice identificativo ISI:||WOS:000296529500008|
|Codice identificativo Scopus:||2-s2.0-80053977979|
|Codice identificativo Pubmed:||20674312|
|Citazione:||Risk for cardiovascular events in an Italian population of patients with type 2 diabetes / E. Pellegrini; M. Maurantonio; I.M. Giannico; M.S. Simonini; D. Ganazzi; L. Carulli; R. D’Amico; A. Baldini; P. Loria; M. Bertolotti; N. Carulli. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - STAMPA. - 21(2011), pp. 885-892.|
|Tipologia||Articolo su rivista|
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