Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity and influenceslearning, memory and cognitive behaviour. The aim of this study is to assess plasma BDNF variations according tohormonal status. METHODS: A total of 60 subjects were included: 20 fertile ovulatory women, 15 amenorrhoeicwomen and 25 postmenopausal women. Blood samples were collected after overnight fasting. For 5 out of the 20fertile women, samples were collected every 2 days throughout the whole menstrual cycle. Following basal evaluation,10 out of 25 postmenopausal women were administered a hormone replacement therapy (HRT) and reevaluated after6 months of treatment. Plasma BDNF concentrations were measured by enzyme-linked immunosorbent assay. Infertile women, estradiol (E2), progesterone and gonadotrophins were also assessed. RESULTS: In fertile women,luteal phase levels of plasma BDNF were significantly higher than follicular phase levels (P < 0.001). BDNF increasedfrom early follicular phase up to Day 14 of the cycle, reaching a pre-ovulatory peak, similar to E2. A second rise tookplace during mid-luteal phase, with a peak on Day 24. Amenorrhoeic subjects, as well as postmenopausal women,showed significantly lower plasma BDNF levels compared with fertile females (P < 0.001). BDNF was positively correlatedwith E2 and progesterone and negatively correlated with menopausal age. HRT restored BDNF levels to thosepresent in fertile women during the follicular phase. CONCLUSIONS: Plasma BDNF levels are influenced by hormonalstatus. Modifications in BDNF circulating levels during the menstrual cycle suggest a potential role for gonadal sexhormones (E2 and progesterone) in regulating neurotrophin expression.
Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor / Begliomini, S; Casarosa, E; Pluchino, N; Lenzi, E; Centofanti, M; Freschi, L; Pieri, M; Genazzani, Alessandro; Luisi, S; Genazzani, A. R.. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 22:4(2007), pp. 995-1002. [10.1093/humrep/del479]
Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor
GENAZZANI, Alessandro;
2007
Abstract
Brain-derived neurotrophic factor (BDNF) is a mediator of neuronal plasticity and influenceslearning, memory and cognitive behaviour. The aim of this study is to assess plasma BDNF variations according tohormonal status. METHODS: A total of 60 subjects were included: 20 fertile ovulatory women, 15 amenorrhoeicwomen and 25 postmenopausal women. Blood samples were collected after overnight fasting. For 5 out of the 20fertile women, samples were collected every 2 days throughout the whole menstrual cycle. Following basal evaluation,10 out of 25 postmenopausal women were administered a hormone replacement therapy (HRT) and reevaluated after6 months of treatment. Plasma BDNF concentrations were measured by enzyme-linked immunosorbent assay. Infertile women, estradiol (E2), progesterone and gonadotrophins were also assessed. RESULTS: In fertile women,luteal phase levels of plasma BDNF were significantly higher than follicular phase levels (P < 0.001). BDNF increasedfrom early follicular phase up to Day 14 of the cycle, reaching a pre-ovulatory peak, similar to E2. A second rise tookplace during mid-luteal phase, with a peak on Day 24. Amenorrhoeic subjects, as well as postmenopausal women,showed significantly lower plasma BDNF levels compared with fertile females (P < 0.001). BDNF was positively correlatedwith E2 and progesterone and negatively correlated with menopausal age. HRT restored BDNF levels to thosepresent in fertile women during the follicular phase. CONCLUSIONS: Plasma BDNF levels are influenced by hormonalstatus. Modifications in BDNF circulating levels during the menstrual cycle suggest a potential role for gonadal sexhormones (E2 and progesterone) in regulating neurotrophin expression.Pubblicazioni consigliate
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