Network analysis has emerged as a powerful approach to understand complex phenomena and organization in social, technological and biological systems. In particular, it is increasingly recognized the role played by the topology of cellular networks, the intricate web of interactions among genes, proteins and other molecules regulating cell activity, in unveiling the biological mechanisms underlying the physiological states of living organisms. In this study, critical analysis of network components has been applied to inspect the transcriptional and post-transcriptional regulatory networks reconstructed from mRNA and microRNA expression data of multiple myeloma (MM) samples. Specifically, the importance of a gene as a putative regulatory element has been assessed calculating the drop in the network performance caused by its deactivation instead of quantifying its degree of connectivity. The application of critical analysis to transcriptional and post-transcriptional regulatory networks allowed inferring novel regulatory relations potentially functional in multiple myeloma

Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma / Biasiolo, M; Forcato, Mattia; Possamai, L; Ferrari, Francesco; Agnelli, L; Lionetti, M; Todoerti, K; Neri, A; Marchiori, M; Bortoluzzi, S; Bicciato, Silvio. - In: PACIFIC SYMPOSIUM ON BIOCOMPUTING. - ISSN 1793-5091. - ELETTRONICO. - 2010:(2010), pp. 397-408. (Intervento presentato al convegno 15th Pacific Symposium on Biocomputing, PSB 2010 tenutosi a Kamuela, HI, usa nel 2010).

Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma

FORCATO, Mattia;FERRARI, Francesco;BICCIATO, Silvio
2010

Abstract

Network analysis has emerged as a powerful approach to understand complex phenomena and organization in social, technological and biological systems. In particular, it is increasingly recognized the role played by the topology of cellular networks, the intricate web of interactions among genes, proteins and other molecules regulating cell activity, in unveiling the biological mechanisms underlying the physiological states of living organisms. In this study, critical analysis of network components has been applied to inspect the transcriptional and post-transcriptional regulatory networks reconstructed from mRNA and microRNA expression data of multiple myeloma (MM) samples. Specifically, the importance of a gene as a putative regulatory element has been assessed calculating the drop in the network performance caused by its deactivation instead of quantifying its degree of connectivity. The application of critical analysis to transcriptional and post-transcriptional regulatory networks allowed inferring novel regulatory relations potentially functional in multiple myeloma
2010
15th Pacific Symposium on Biocomputing, PSB 2010
Kamuela, HI, usa
2010
2010
397
408
Biasiolo, M; Forcato, Mattia; Possamai, L; Ferrari, Francesco; Agnelli, L; Lionetti, M; Todoerti, K; Neri, A; Marchiori, M; Bortoluzzi, S; Bicciato, S...espandi
Critical analysis of transcriptional and post-transcriptional regulatory networks in multiple myeloma / Biasiolo, M; Forcato, Mattia; Possamai, L; Ferrari, Francesco; Agnelli, L; Lionetti, M; Todoerti, K; Neri, A; Marchiori, M; Bortoluzzi, S; Bicciato, Silvio. - In: PACIFIC SYMPOSIUM ON BIOCOMPUTING. - ISSN 1793-5091. - ELETTRONICO. - 2010:(2010), pp. 397-408. (Intervento presentato al convegno 15th Pacific Symposium on Biocomputing, PSB 2010 tenutosi a Kamuela, HI, usa nel 2010).
File in questo prodotto:
File Dimensione Formato  
9789814295291_0042.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 3.23 MB
Formato Adobe PDF
3.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/639874
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact