In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebrate and vertebrate cell cultures. OA and PTX, two toxins with a better established mode of action, are analyzed with regard to their effects on development. The amphibian Xenopus laevis is used as a model, and the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) as the experimental protocol.
Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review. Mar. Drugs / Franchini, Antonella; Malagoli, Davide; Ottaviani, Enzo. - In: MARINE DRUGS. - ISSN 1660-3397. - STAMPA. - 8:3(2010), pp. 658-677. [10.3390/md8030658]
Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review. Mar. Drugs
FRANCHINI, Antonella;MALAGOLI, Davide;OTTAVIANI, Enzo
2010
Abstract
In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebrate and vertebrate cell cultures. OA and PTX, two toxins with a better established mode of action, are analyzed with regard to their effects on development. The amphibian Xenopus laevis is used as a model, and the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) as the experimental protocol.
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