We found that Clu is down regulated during cancer progression in humans and in the TRAMP model. We reasoned that Knock down of Clu ( CLU KO mice) in a suitable prostate cancer model would affect disease progression. After crossing Clu KO with TRAMP mice, we observed a higher cancer invasion spreading in many different body sites including kidney and liver. In situ neoplastic and metastatic lesions, all positive for SV40 antigen transgene, were also consistently Ki67- and NF-kB- positive in TRAMP CLU-/- if compared to TRAMP CLU+/+ mice. Interestingly and surprisingly CLU depletion causes tumurigenesis in female TRAMP mice, which are normally cancer free.

Effects of CLU knock down on prostate cancer progression in the TRAMP model / S., Davoli; Davalli, Pierpaola; O., Chayka; F., Rizzi; D., Pellacani; G., Fregni; Astancolle, Serenella; M., Fassan; Corti, Arnaldo; R., Baffa; A., Sala; S., Bettuzzi. - In: THE FEBS JOURNAL. - ISSN 1742-4658. - STAMPA. - 276(2009), pp. 363-364. ((Intervento presentato al convegno 34° FEBS Congress tenutosi a Praga nel 4-9-luglio 2009.

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Powered by IRIS-about IRIS-Utilizzo dei cookie

 Copyright © 2022