Granules of hydroxyapatite (HA) and tricalcium phosphate (TCP) were implanted in separate holes drilled in mandibular bone of sheep to check the bone growth and in vivo behaviour of the materials. The experiment was performed in three sheep, killed respectively at 4, 8, 12 month. Samples of bone with the materials were explanted, microradiographed and sectioned to evaluate the interface under optical and electron scanning electron microscope. The hole, left empty as a reference, showed no full repair; whereas 4 month after implantation the TCP granules induce total repair of the hole. HA granules crumbled and no new bone induction was seen even 12 month after implantation.
Behavior Of Tricalcium Phosphate And Hydroxyapatite Granules In Sheep Bone Defects / Gatti, Antonietta; Zaffe, Davide; G. P., Poli. - In: BIOMATERIALS. - ISSN 0142-9612. - STAMPA. - 11:(1990), pp. 513-517. [10.1016/0142-9612(90)90068-2]
Behavior Of Tricalcium Phosphate And Hydroxyapatite Granules In Sheep Bone Defects
GATTI, Antonietta;ZAFFE, Davide;
1990
Abstract
Granules of hydroxyapatite (HA) and tricalcium phosphate (TCP) were implanted in separate holes drilled in mandibular bone of sheep to check the bone growth and in vivo behaviour of the materials. The experiment was performed in three sheep, killed respectively at 4, 8, 12 month. Samples of bone with the materials were explanted, microradiographed and sectioned to evaluate the interface under optical and electron scanning electron microscope. The hole, left empty as a reference, showed no full repair; whereas 4 month after implantation the TCP granules induce total repair of the hole. HA granules crumbled and no new bone induction was seen even 12 month after implantation.
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