In this study we wished to test the feasibility of predicting the perceived pain intensity in healthy volunteers, based on fMRI signals collected during an experimental pain paradigm lasting several minutes. This model of acute prolonged (tonic) pain bears some similarities with clinically relevant conditions, such as prolonged ongoing activity in nociceptors and spontaneous fluctuations of perceived pain intensity over time.To predict individual pain profile, we tested and optimized one methodological approach based on new regularization learning algorithms on this regression problem.
A regularization algorithm for decoding perceptual profiles / Favilla, Stefania; Prato, Marco; Zanni, Luca; Porro, Carlo Adolfo; Baraldi, Patrizia. - STAMPA. - (2010), pp. 1278-1278.