Antibodies to the platelet factor 4/heparin complex are linked to the pathogenesis of heparin-induced thrombocytopenia type II (HIT II) and the thrombotic complications associated with this syndromeThe aim of the study was to evaluate the relationship between thrombotic events and the ELISA optical density.Methods. 140 consecutive patients (pts) with NSTEMI were included in the study. An immunoassay ELISA test was used to detect heparin/PF4 antibodies. Blood samples were taken after 8 ± 2.7 days from heparin. Platelets and nutritional status were measured. Unpaired test or variance analysis was used to compare clinical variables. The primary endpoint was a composite of death from any cause, new myocardial infarction, and new thrombotic events
Thrombotic events in patients with anti-platelet factor 4/heparin antibodies / Mattioli, Anna Vittoria; Bonetti, L.; Fontanesi, L.; Castellana, N.; Tarabini Castellani, E.; Melotti, R.; Mattioli, Giorgio. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 29:(2008), pp. 828-828. (Intervento presentato al convegno European Society of Cardiology Congress 2008 tenutosi a Munich, Germany nel 30 agosto-3 settembre 2008).
Thrombotic events in patients with anti-platelet factor 4/heparin antibodies
MATTIOLI, Anna Vittoria;E. Tarabini Castellani;MATTIOLI, Giorgio
2008
Abstract
Antibodies to the platelet factor 4/heparin complex are linked to the pathogenesis of heparin-induced thrombocytopenia type II (HIT II) and the thrombotic complications associated with this syndromeThe aim of the study was to evaluate the relationship between thrombotic events and the ELISA optical density.Methods. 140 consecutive patients (pts) with NSTEMI were included in the study. An immunoassay ELISA test was used to detect heparin/PF4 antibodies. Blood samples were taken after 8 ± 2.7 days from heparin. Platelets and nutritional status were measured. Unpaired test or variance analysis was used to compare clinical variables. The primary endpoint was a composite of death from any cause, new myocardial infarction, and new thrombotic events
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