Background. Antibodies to the heparin/platelet factor 4 (PF4) complex are linked to the pathogenesis of heparin-induced thrombocytopenia type II, and to the thrombotic complications associated with this syndrome. Because these antibodies may activate vascular endothelium as well as platelets, their presence may possibly increase the risk of thrombotic events. We investigated the long-term relationship between antibody concentration and thrombosis. Methods and results. Two-hundred and fifty patients who had been treated with unfractionated heparin as part of cardiac surgery management were included in the study. Immunoassay ELISA test was used to detect the presence and the plasma concentration of heparin-PF4 antibodies. Follow-up lasted one year and new thrombotic events (myocardial infarction, stroke, pulmonary embolism), and death from any cause, were evaluated
Thrombotic events in patients with antiplatelet factor 4/Heparin antibodies after cardiac surgery / Mattioli, Anna Vittoria; L., Bonetti; U., Carletti; R., Vivoli; G., Ambrosio; Mattioli, Giorgio. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - STAMPA. - 53:10(2009), pp. A448-A448. (Intervento presentato al convegno American College of Cardiology Scientific Session tenutosi a Orlando, USA nel 29-31 marzo 2009).
Thrombotic events in patients with antiplatelet factor 4/Heparin antibodies after cardiac surgery
MATTIOLI, Anna Vittoria;MATTIOLI, Giorgio
2009
Abstract
Background. Antibodies to the heparin/platelet factor 4 (PF4) complex are linked to the pathogenesis of heparin-induced thrombocytopenia type II, and to the thrombotic complications associated with this syndrome. Because these antibodies may activate vascular endothelium as well as platelets, their presence may possibly increase the risk of thrombotic events. We investigated the long-term relationship between antibody concentration and thrombosis. Methods and results. Two-hundred and fifty patients who had been treated with unfractionated heparin as part of cardiac surgery management were included in the study. Immunoassay ELISA test was used to detect the presence and the plasma concentration of heparin-PF4 antibodies. Follow-up lasted one year and new thrombotic events (myocardial infarction, stroke, pulmonary embolism), and death from any cause, were evaluated
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