Recent advances in comparative immunology have established that invertebrates produce hypervariable molecules probably related to immunity, suggesting the possibility of raising a specific immune response. "Priming" and "tailoring" are terms now often associated with the invertebrate innate immunity. Comparative immunologists contributed to eliminate the idea of a static immune system in invertebrates, making necessary to re-consider the evolutive meaning of immunological memory of vertebrates. If the anticipatory immune system represents a maximally efficient immune system, why can it be observed only in vertebrates, especially in consideration that molecular hypervariability exists also in invertebrates? Using well-established theories concerning the evolution of the vertebrate immunity as theoretical basis we analyze from an Eco-immunology-based perspective why a memory-based immune system may have represented an evolutive advantage for jawed vertebrates. We hypothesize that for cold-blooded vertebrates memory represents a complimentary component that flanks the robust and fundamental innate immunity. Conversely, immunological memory has become indispensable and fully exploited in warm-blooded vertebrates, due to their stable inner environment and high metabolic rate, respectively.
Life is a huge compromise: Is the complexity of the vertebrate immune-neuroendocrine system an advantage or the price to pay? / Malagoli, Davide; Ottaviani, Enzo. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART A, MOLECULAR & INTEGRATIVE PHYSIOLOGY. - ISSN 1095-6433. - STAMPA. - 155(2010), pp. 134-138. [10.1016/j.cbpa.2009.10.031]
Data di pubblicazione: | 2010 | |
Titolo: | Life is a huge compromise: Is the complexity of the vertebrate immune-neuroendocrine system an advantage or the price to pay? | |
Autore/i: | Malagoli, Davide; Ottaviani, Enzo | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.cbpa.2009.10.031 | |
Rivista: | ||
Volume: | 155 | |
Pagina iniziale: | 134 | |
Pagina finale: | 138 | |
Codice identificativo ISI: | WOS:000273926200002 | |
Codice identificativo Scopus: | 2-s2.0-72049098171 | |
Codice identificativo Pubmed: | 19879954 | |
Citazione: | Life is a huge compromise: Is the complexity of the vertebrate immune-neuroendocrine system an advantage or the price to pay? / Malagoli, Davide; Ottaviani, Enzo. - In: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART A, MOLECULAR & INTEGRATIVE PHYSIOLOGY. - ISSN 1095-6433. - STAMPA. - 155(2010), pp. 134-138. [10.1016/j.cbpa.2009.10.031] | |
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