Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA / M., Guescini; Genedani, Susanna; V., Stocchi; Agnati, Luigi Francesco. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 117:1(2010), pp. 1-4. [10.1007/s00702-009-0288-8]

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

GENEDANI, Susanna;AGNATI, Luigi Francesco
2010

Abstract

Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.
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Astrocytes and Glioblastoma cells release exosomes carrying mtDNA / M., Guescini; Genedani, Susanna; V., Stocchi; Agnati, Luigi Francesco. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - STAMPA. - 117:1(2010), pp. 1-4. [10.1007/s00702-009-0288-8]
M., Guescini; Genedani, Susanna; V., Stocchi; Agnati, Luigi Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/635881
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