The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain / Alboni, Silvia; Cervia, D; Ross, B; Montanari, Claudia; Gonzalez, As; Sanchez Alavez, M; Marcondes, Mc; De Vries, D; Sugama, S; Brunello, Nicoletta; Blom, Johanna Maria Catharina; Tascedda, Fabio; Conti, B.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 214:1-2(2009), pp. 43-54. [10.1016/j.jneuroim.2009.06.016]
Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain
ALBONI, Silvia;MONTANARI, Claudia;BRUNELLO, Nicoletta;BLOM, Johanna Maria Catharina;TASCEDDA, Fabio;
2009
Abstract
The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
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