EnglishThe cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed in neurons throughout the brain primarily with overlapping distribution but also with some unique pattern. These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor.
Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain / Alboni, Silvia; Cervia, D; Ross, B; Montanari, Claudia; Gonzalez, As; Sanchez Alavez, M; Marcondes, Mc; De Vries, D; Sugama, S; Brunello, Nicoletta; Blom, Johanna Maria Catharina; Tascedda, Fabio; Conti, B.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 214(1-2)(2009), pp. 43-54.
| Data di pubblicazione: | 2009 | |
| Titolo: | Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain | |
| Autore/i: | Alboni, Silvia; Cervia, D; Ross, B; Montanari, Claudia; Gonzalez, As; Sanchez Alavez, M; Marcondes, Mc; De Vries, D; Sugama, S; Brunello, Nicoletta; Blom, Johanna Maria Catharina; Tascedda, Fabio; Conti, B. | |
| Autore/i UNIMORE: | ||
| Rivista: | ||
| Volume: | 214(1-2) | |
| Pagina iniziale: | 43 | |
| Pagina finale: | 54 | |
| Codice identificativo ISI: | WOS:000270697000004 | |
| Codice identificativo Scopus: | 2-s2.0-69949179196 | |
| Codice identificativo Pubmed: | 19640592 | |
| Citazione: | Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain / Alboni, Silvia; Cervia, D; Ross, B; Montanari, Claudia; Gonzalez, As; Sanchez Alavez, M; Marcondes, Mc; De Vries, D; Sugama, S; Brunello, Nicoletta; Blom, Johanna Maria Catharina; Tascedda, Fabio; Conti, B.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 214(1-2)(2009), pp. 43-54. | |
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