BACKGROUND: To evaluate the activity and safety of nonpegylated liposomal doxorubicin (Myocet) when substituted for doxorubicin in the R-CHOP regimen (R-COMP). PATIENTS AND METHODS: Seventy-five elderly patients with diffuse large B-cell lymphoma (DLBCL) were studied. Only patients with left ventricular ejection fraction (LVEF) >/=50% were allowed. R-COMP regimen was administered every 3 weeks for three cycles, followed by additional five cycles in case of complete response (CR) or partial response. RESULTS: From November 2002 to April 2005, 75 patients were registered, of which 72 were evaluated. Median age was 72 years (range 61-83); 56% of patients had high or high-intermediate International Prognostic Index score. Median LVEF at baseline was 61%. Thirty-eight patients had history of abnormal cardiovascular conditions. The overall response rate was 71%, with a CR rate of 57%. After a median follow-up of 33 months, the 3-year overall survival, failure-free survival, and progression-free survival rates were 72%, 39%, and 69%, respectively. Neutropenia (54%) was the most frequent grade 3-4 adverse event (AE); 21% of patients experienced cardiac AEs, graded as 3-4 in 4% of the cases. CONCLUSION: R-COMP is an effective regimen for the treatment of DLBCL in elderly patients, with an acceptable tolerability profile.
Nonpegylated liposomal doxorubicin (Myocet) combination (R-COMP) chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL): results from the phase II EURO 18 trial / Luminari, Stefano; Montanini, Antonella; Caballero, D.; Bologna, S.; Notter, M.; Dyer, M. J. S.; Chiappella, A.; Briones, J.; Petrini, M.; Barbato, A.; Kayitalire, L.; Federico, Massimo. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 21 (7):(2010), pp. 1492-1499. [10.1093/annonc/mdp544]
Data di pubblicazione: | 2010 | |
Titolo: | Nonpegylated liposomal doxorubicin (Myocet) combination (R-COMP) chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL): results from the phase II EURO 18 trial | |
Autore/i: | Luminari, Stefano; Montanini, Antonella; Caballero, D.; Bologna, S.; Notter, M.; Dyer, M. J. S.; Chiappella, A.; Briones, J.; Petrini, M.; Barbato, A.; Kayitalire, L.; Federico, Massimo | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/annonc/mdp544 | |
Rivista: | ||
Volume: | 21 (7) | |
Pagina iniziale: | 1492 | |
Pagina finale: | 1499 | |
Codice identificativo ISI: | WOS:000279185200016 | |
Codice identificativo Scopus: | 2-s2.0-77954334532 | |
Codice identificativo Pubmed: | 20007997 | |
Citazione: | Nonpegylated liposomal doxorubicin (Myocet) combination (R-COMP) chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL): results from the phase II EURO 18 trial / Luminari, Stefano; Montanini, Antonella; Caballero, D.; Bologna, S.; Notter, M.; Dyer, M. J. S.; Chiappella, A.; Briones, J.; Petrini, M.; Barbato, A.; Kayitalire, L.; Federico, Massimo. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 21 (7):(2010), pp. 1492-1499. [10.1093/annonc/mdp544] | |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
Ann Oncol-2010-Luminari-1492-9.pdf | Post-print dell'autore (bozza post referaggio) | Administrator Richiedi una copia |
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris