Background. Although the University of Wisconsin (U.W.) solution continues to be the most commonly used for intra-abdominal organs, a new solution, Celsior, already used for heart and lungs, has been proposed for kidney and liver preservation. The aim of this research was to assess the effect of Celsior as compared with U.W. on immediate graft function and a 2-year follow-up of kidney transplants. Methods. A prospective multicenter randomized study was designed to evaluate the efficacy of the Celsior solution in the clinical preservation of the kidney. In this report, we present the data collected as of September 2000. One hundred donors were included in the trial resulting in 187 renal transplants. Ninety-nine kidneys were stored in Celsior solution and 88 in U.W. solution. The groups were comparable with regard to donor and recipient characteristics. Results. Delayed graft function occurred in 31.3% of the Celsior group and in 33.9% of the U.W. group (P=n.s.). Mean serum creatinine levels and mean daily urinary output were also comparable. Two year graft survival in kidneys preserved with Celsior was 84% as compared with 75% for U.W.-preserved kidneys without any significant statistical difference. Conclusions. Our data show that the preservation of kidneys in Celsior solution in a clinical setting is equivalent to that of U.W. solution. When using Celsior during multiple-organ donor harvesting it would be possible to perform an in situ Rush of all intra-abdominal and intrathoracie organs with a single cold storage solution.

Kidney preservation with university of Wisconsin and Celsior solution: A prospective multicenter randomized study / Faenza, A; Catena, F; Nardo, B; Montalti, R; Capocasale, E; Busi, N; Boggi, U; Vistoli, F; Di Naro, A; Albertazzi, Alberto; Mosca, F; Cavallari, A.. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 72:(2001), pp. 1274-1277.

Kidney preservation with university of Wisconsin and Celsior solution: A prospective multicenter randomized study.

ALBERTAZZI, Alberto;
2001-01-01

Abstract

Background. Although the University of Wisconsin (U.W.) solution continues to be the most commonly used for intra-abdominal organs, a new solution, Celsior, already used for heart and lungs, has been proposed for kidney and liver preservation. The aim of this research was to assess the effect of Celsior as compared with U.W. on immediate graft function and a 2-year follow-up of kidney transplants. Methods. A prospective multicenter randomized study was designed to evaluate the efficacy of the Celsior solution in the clinical preservation of the kidney. In this report, we present the data collected as of September 2000. One hundred donors were included in the trial resulting in 187 renal transplants. Ninety-nine kidneys were stored in Celsior solution and 88 in U.W. solution. The groups were comparable with regard to donor and recipient characteristics. Results. Delayed graft function occurred in 31.3% of the Celsior group and in 33.9% of the U.W. group (P=n.s.). Mean serum creatinine levels and mean daily urinary output were also comparable. Two year graft survival in kidneys preserved with Celsior was 84% as compared with 75% for U.W.-preserved kidneys without any significant statistical difference. Conclusions. Our data show that the preservation of kidneys in Celsior solution in a clinical setting is equivalent to that of U.W. solution. When using Celsior during multiple-organ donor harvesting it would be possible to perform an in situ Rush of all intra-abdominal and intrathoracie organs with a single cold storage solution.
72
1274
1277
Kidney preservation with university of Wisconsin and Celsior solution: A prospective multicenter randomized study / Faenza, A; Catena, F; Nardo, B; Montalti, R; Capocasale, E; Busi, N; Boggi, U; Vistoli, F; Di Naro, A; Albertazzi, Alberto; Mosca, F; Cavallari, A.. - In: TRANSPLANTATION. - ISSN 0041-1337. - STAMPA. - 72:(2001), pp. 1274-1277.
Faenza, A; Catena, F; Nardo, B; Montalti, R; Capocasale, E; Busi, N; Boggi, U; Vistoli, F; Di Naro, A; Albertazzi, Alberto; Mosca, F; Cavallari, A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/6307
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 63
  • ???jsp.display-item.citation.isi??? 57
social impact