EnglishUrinary neopterin levels were studied in 96 patients with malignant lymphomas. Twenty-eight had Hodgkin's disease and 68 non-Hodgkin's lymphoma. Neopterin excretion was significantly related to the clinical stage of the disease. Mean neopterin excretion in patients with active disease (634 +/- 527 mumol neopterin/mol creatinine) was significantly higher (p = 0.000) than in patients in complete remission (198 +/- 105 mumol neopterin/mol creatinine). Mean neopterin levels of patients in stage III-IV were higher than for patients in stage I-II. These findings were the same in patients with Hodgkin's disease and those with non-Hodgkin's lymphoma (659 +/- 593-425 +/- 316 mumol neopterin/mol creatinine), regardless of the histological subtype. A significant correlation was found between neopterin excretion, ESR (r = 0.31; p = 0.003) and hemoglobin (r = -0.40; p = 0.000). Longitudinal analysis showed a trend towards a correlation between response to therapy and neopterin excretion. These findings suggest that neopterin may be a useful prognostic marker in non-Hodgkin's lymphoma.
| Data di pubblicazione: | 1991 |
| Titolo: | Urinary neopterin in malignant lymphoma |
| Autore/i: | Piccinini, Lino; Zironi, S.; Federico, Massimo; Pini, Luigi Alberto; Luppi, G. |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 6 (4) |
| Pagina iniziale: | 231 |
| Pagina finale: | 236 |
| Codice identificativo Scopus: | 2-s2.0-0026333943 |
| Codice identificativo Pubmed: | 1795130 |
| Citazione: | Urinary neopterin in malignant lymphoma / Piccinini, Lino; Zironi, S.; Federico, Massimo; Pini, Luigi Alberto; Luppi, G.. - In: THE INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS. - ISSN 0393-6155. - STAMPA. - 6 (4)(1991), pp. 231-236. |
| Tipologia | Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | |
|---|---|---|---|
| Urinary neopterin......pdf | Versione editoriale | Administrator Richiedi una copia |
http://hdl.handle.net/11380/630378
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2019