The cerebellum is a suitable referenceregion for the quantification of mGluR5 availabilitywith [11C]ABP688. Blood sample based quantificationof BPnd correlates well with reference regionbased analyses. Scan duration of 50 mins is required.The observed increase in receptor density in humans(hippocampal specimens) suffering from temporallobe epilepsy was not observed in the pilocarpinemodel, but the stastical power has to be increased toconfirm these results. The present results in thepilocarpine model contrast with the immunohistochemicalstudies in humans but are in agreementwith receptor binding studies conducted by ourgroup.
Evaluation of reference models for [11C]ABP688 targeting the metabotropic glutamate receptor 5 in rats—application to an epilepsy model / Elmenhorst, ; Biagini, Giuseppe; L., Minuzzi; A., Aliaga; G., Massarweh; M., Diksic; M., Avoli; A., Bauer; P., Rosa Neto. - In: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. - ISSN 0271-678X. - STAMPA. - 29:(2009), pp. S71-S72. (Intervento presentato al convegno IXth International Conference on Quantification of Brain Function with PET tenutosi a Chicago nel 29 giugno-3 luglio 2009).
Evaluation of reference models for [11C]ABP688 targeting the metabotropic glutamate receptor 5 in rats—application to an epilepsy model
BIAGINI, Giuseppe;
2009
Abstract
The cerebellum is a suitable referenceregion for the quantification of mGluR5 availabilitywith [11C]ABP688. Blood sample based quantificationof BPnd correlates well with reference regionbased analyses. Scan duration of 50 mins is required.The observed increase in receptor density in humans(hippocampal specimens) suffering from temporallobe epilepsy was not observed in the pilocarpinemodel, but the stastical power has to be increased toconfirm these results. The present results in thepilocarpine model contrast with the immunohistochemicalstudies in humans but are in agreementwith receptor binding studies conducted by ourgroup.
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