Microscopic haematuria is a urinary finding more and more frequently observed in routine analysis in childhood. The diagnostic problems, most of which unresolved, are yet the principal question concerning in. We have studied 123 patients during five years from 1975 to 1980, and followed them for 1-8 years (mean 4 years). Oue experience allowed us to consider “normal” or without remarkable pathologic significance a urinary findings less than or equal to 5,000 RBC/m’ at the Addis count. Such findings was pointed out in 55 cases (44%); 27 patients (22%) had 5-10,000 RBC/m’, 34 patients (27.6%) presented 10-50,000 RBC/m’, and 7 cases (5.7%) had more than 50,000 RBC/m’. The familiar background, the clinical, biological, and immunological data, the roentgenographic investigations and the renal biopsy carried out in 4 group of patients, led us to the following conclusions: (1) 26% of the 123 cases had an “unexplained” microscopic haematuria with complete lack of anamnestic data, symptomatology and with normal biological findings. (2) In 65.8% of the cases it was possible to discover frequent upper respiratory tract infections (and allergy in 5.6% of them). (3)In 26% of the patients we discovered a previous or actual genitor-urinary (10.5% and 15.5% respectively) infection: 9.4% of 96 urographies demonstrated a variable degree of nephro-urological abnormalities. (4) 23 children (18.7%) was selected for renal biopsy, primarily by the hypocomplementemia and positive anti-DNA ab. Test, and secondly by elevated degree of microematuria. The histological and immunohistochemical studies demonstrated the presence of mesangial proliferation glomerulonephritis with IgC-IgA-C3 deposits in 7 cases (30% of the cases biopsied and 5.6% of the total), 69.6% of the cases had only minimal changes with negative immunofluorescence. (5) A mean follow-up of 4 years in two groups of patients (<and> 6 years of age) has demonstrated that microscopic haematuria remains unchanged in 18-19% of both groups. A more marked improvement or normalization has been documented in the children more than 6 years aged (p<0.001) while a worsening has been observed in the children less than 6 years aged (p<0.005), with a difference statistically significant between the two groups considered.
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|Anno di pubblicazione:||1982|
|Titolo:||La microematuria asintomatica|
|Autori:||T. Cappellini; A. Guerra; F. Canonaco; R. Genova; M. Lalla|
|Appare nelle tipologie:||Articolo su rivista|
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