The hepatic involvement in Hodgkin's disease, histologically verified in 133 patients who underwent laparotomy or laparoscopy, proved to be singly related to the following clinical findings: result of the liver isotopic scan, liver and/or spleen enlargement, serum albumin less than or equal to 3.5 g/dl, GOT and/or GPT greater than or equal to 20 mU/ml, serum alkaline phosphatase (SAP) greater than or equal to 210 mU/ml, BSP retention at 45 min greater than or equal to 6.5% and ESR greater than or equal to 51 mm at 1 hr. Such clinical findings were jointly evaluated and further selected by means of a logistic discriminant analysis, and the simplest function with the best discriminant ability between involved and non-involved liver was made by liver scan, spleen enlargement, BSP retention and GOT (89.5% of correct diagnoses). Since the Ann Arbor clinical criteria for liver involvement showed correct diagnoses in 69-80% of the cases, more reliable criteria can be proposed. So, liver involvement is highly probably (a) when three or more of the five variables indicated above are abnormal, or (b) when a markedly abnormal liver scan is associated with alteration of at least one of the other four parameters: otherwise liver will be non-involved.

New clinical criteria for the assessment of liver involvement in Hodgkin's disease / Gobbi, P. G.; Attardo Parrinello, G.; DI PRISCO, Alfredo Ubaldo; Federico, Massimo; Bonacorsi, G.; Dini, D.; Marabelli, S.; Rizzo, S. C.; Ascari, E.. - In: EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY. - ISSN 0277-5379. - STAMPA. - 18 (12):(1982), pp. 1243-1249. [10.1016/0277-5379(82)90125-0]

New clinical criteria for the assessment of liver involvement in Hodgkin's disease

DI PRISCO, Alfredo Ubaldo;FEDERICO, Massimo;
1982

Abstract

The hepatic involvement in Hodgkin's disease, histologically verified in 133 patients who underwent laparotomy or laparoscopy, proved to be singly related to the following clinical findings: result of the liver isotopic scan, liver and/or spleen enlargement, serum albumin less than or equal to 3.5 g/dl, GOT and/or GPT greater than or equal to 20 mU/ml, serum alkaline phosphatase (SAP) greater than or equal to 210 mU/ml, BSP retention at 45 min greater than or equal to 6.5% and ESR greater than or equal to 51 mm at 1 hr. Such clinical findings were jointly evaluated and further selected by means of a logistic discriminant analysis, and the simplest function with the best discriminant ability between involved and non-involved liver was made by liver scan, spleen enlargement, BSP retention and GOT (89.5% of correct diagnoses). Since the Ann Arbor clinical criteria for liver involvement showed correct diagnoses in 69-80% of the cases, more reliable criteria can be proposed. So, liver involvement is highly probably (a) when three or more of the five variables indicated above are abnormal, or (b) when a markedly abnormal liver scan is associated with alteration of at least one of the other four parameters: otherwise liver will be non-involved.
1982
18 (12)
1243
1249
New clinical criteria for the assessment of liver involvement in Hodgkin's disease / Gobbi, P. G.; Attardo Parrinello, G.; DI PRISCO, Alfredo Ubaldo; Federico, Massimo; Bonacorsi, G.; Dini, D.; Marabelli, S.; Rizzo, S. C.; Ascari, E.. - In: EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY. - ISSN 0277-5379. - STAMPA. - 18 (12):(1982), pp. 1243-1249. [10.1016/0277-5379(82)90125-0]
Gobbi, P. G.; Attardo Parrinello, G.; DI PRISCO, Alfredo Ubaldo; Federico, Massimo; Bonacorsi, G.; Dini, D.; Marabelli, S.; Rizzo, S. C.; Ascari, E....espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/626661
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