Using an ESR spectrometer, we studied the time course of the uptake of the liposome-entrapped spin label 2,2,6,6-tetramethylpiperidine-N-oxyl-4-trimethylammonium in liver, spleen, and bone marrow following reticuloendothelial liver blockade. Our results show that suppression of the phagocytic activity of the liver increases the delivery of liposomes to the spleen and bone marrow without substantially altering uptake by the liver.
Bone marrow uptake of liposome-entrapped spin label after liver blockade with empty liposomes / Federico, Massimo; Iannone, Anna; Chan, H. C.; Magin, R. L.. - In: MAGNETIC RESONANCE IN MEDICINE. - ISSN 0740-3194. - STAMPA. - 10:(1989), pp. 418-425. [10.1002/mrm.1910100314]
Bone marrow uptake of liposome-entrapped spin label after liver blockade with empty liposomes
FEDERICO, Massimo;IANNONE, Anna;
1989
Abstract
Using an ESR spectrometer, we studied the time course of the uptake of the liposome-entrapped spin label 2,2,6,6-tetramethylpiperidine-N-oxyl-4-trimethylammonium in liver, spleen, and bone marrow following reticuloendothelial liver blockade. Our results show that suppression of the phagocytic activity of the liver increases the delivery of liposomes to the spleen and bone marrow without substantially altering uptake by the liver.
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