Dextran magnetite (DM) is a potential MR contrast agent with superparamagnetic properties. Its fast clearance from the blood and selective uptake by tissue macrophages provide advantages for imaging tumors in the liver and spleen. DM consists of a suspension of solid particles with a wide distribution of sizes. In this study we have used ESR spectroscopy to determine the blood clearance of DM injected iv in mice. The spectra are obtained on living animals by inserting the tail of a mice into the waveguide cavity of the ESR spectrometer and recording the ESR spectrum continuously. This procedure allows the direct measurement of the plasma clearance of DM from individual animals, without blood sampling. We applied this method to study the clearance of suspensions of DM particles with different average sizes.
Blood clearance of dextran magnetite particles by a non invasive in vivo ESR method / Iannone, Anna; Magin, R. L.; Walczac, T.; Federico, Massimo; Swartz, H. M.; Tomasi, Aldo; Vannini, V.. - In: MAGNETIC RESONANCE IN MEDICINE. - ISSN 0740-3194. - STAMPA. - 22:(1991), pp. 435-442. [10.1002/mrm.1910220251]
Blood clearance of dextran magnetite particles by a non invasive in vivo ESR method
IANNONE, Anna;FEDERICO, Massimo;TOMASI, Aldo;
1991
Abstract
Dextran magnetite (DM) is a potential MR contrast agent with superparamagnetic properties. Its fast clearance from the blood and selective uptake by tissue macrophages provide advantages for imaging tumors in the liver and spleen. DM consists of a suspension of solid particles with a wide distribution of sizes. In this study we have used ESR spectroscopy to determine the blood clearance of DM injected iv in mice. The spectra are obtained on living animals by inserting the tail of a mice into the waveguide cavity of the ESR spectrometer and recording the ESR spectrum continuously. This procedure allows the direct measurement of the plasma clearance of DM from individual animals, without blood sampling. We applied this method to study the clearance of suspensions of DM particles with different average sizes.File | Dimensione | Formato | |
---|---|---|---|
Blood clearance of .......pdf
Accesso riservato
Tipologia:
Versione pubblicata dall'editore
Dimensione
3.16 MB
Formato
Adobe PDF
|
3.16 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris