Evaluation in vitro skin permeation of glycolic acid from two different skin formulation and comparison the in vitro data with those obtained in vivo by means tape-stripping technique in humans. As far as the vehicle influence, in vivo glycolic acid skin permeation extent was predicted by the in vitro data. On the contrary, the in vitro assay provided an overestimation of absorption that can be probably explained by glycolic acid penetration into the unremoved stratum corneum layers.
In vitro and in vivo skin permeation of glycolic acid / Iannuccelli, Valentina; S., Scalia; Bellini, Alessia; Sergi, Santo; Coppi, Gilberto. - STAMPA. - ND:(2009), pp. 113-113. (Intervento presentato al convegno Skin and Formulation, 3rd Symposium and Skin Forum, 10th Annual Meeting tenutosi a Versailles, Francia nel 9-10 marzo 2009).
In vitro and in vivo skin permeation of glycolic acid
IANNUCCELLI, Valentina;BELLINI, ALESSIA;SERGI, Santo;COPPI, Gilberto
2009
Abstract
Evaluation in vitro skin permeation of glycolic acid from two different skin formulation and comparison the in vitro data with those obtained in vivo by means tape-stripping technique in humans. As far as the vehicle influence, in vivo glycolic acid skin permeation extent was predicted by the in vitro data. On the contrary, the in vitro assay provided an overestimation of absorption that can be probably explained by glycolic acid penetration into the unremoved stratum corneum layers.
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