Paraoxonase (PON) is a calcium-dependent HDL-associated ester hydrolase catalizying hydrolysis of organophosphates. Its biological role is still unknown: experimental studies suggest a hydroperoxidasic activity on lipoperoxides formed during LDL-oxidation, thus acting as a protective agent against atherogenesis. We evaluated PON activity in healthy subjects (HS) and in patients with cardiovascular (CHD) and cerebrovascular (CVD) disease ; PON activity was correlated with plasma malonyldialdeide (MDA) levels, as markers of lipid peroxidation Materials and Methods: 33 HS (age 7012 yr), 45 CHD (age 818 yr) and 38 CVD (age 8011 yr) patients were studied. Serum PON and plasma MDA levels were measured spectrophotometrically. Statististical analysis was performed by ANOVA univariate for groups comparation and by Pearson r test for values correlation Results: PON activity (mol min-1 ml-1) is higher in HS (0.0750.03) than in CHD (0.0450.03) and CVD (0.0560.03) patients (p<0.05 HS vs. CHD and CVD; ns CHD vs. CVD). MDA (mol/ml) levels are lower in HS (0.0280.023) than in CHD (0.0630.012) and in CVD (0.0560.036) patients (p<0.05 in HS vs. CHD and CVD, ns in CHD vs CVD). Table shows correlation between PON activity and MDA plasma levels in the three studied groups are shown below. rsignificanceHS-.43 p<0.05CHD-.39 p<0.01CVD-.33 p<0.05Conclusions: PON activity is significatively higher in HS than in CHD and CVD patients; whereas there are no significant difference between CHD e CVD patients. In all groups there is statistically significant negative correlation between PON activity and lipid peroxides content (MDA levels) in plasma. Our results suggest a protective role of PON activity against atherogenesis occurring with higher levels of lipoperoxides.
|Data di pubblicazione:||1997|
|Titolo:||Correlation between plasma malonyldialdeide levels and paroxonase activity in healthy subjects and in patients with atherosclerotic disease|
|Autori:||G. Scarpetta; P. Ventura; R. Panini; G. Salvioli|
|Nome del convegno:||XI National congress of the Italian Society for the study of atherosclerosis|
|Luogo del convegno:||Vibo Valentia|
|Data del convegno:||1-2 dicembre 1997|
|Volume:||135 (suppl 1)|
|Appare nelle tipologie:||Abstract in Rivista|
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