OBJECTIVES: The aim of this prospective study was to identify the combination of parameters best able to predict the diagnosis of compensated cirrhosis. METHODS: One hundred and fourteen patients with suspected chronic compensated liver disease were divided, on the basis of bioptical findings, into two groups: group A, without cirrhosis (n = 58) and group B, with cirrhosis (n = 56). A number of biochemical parameters, the extent of oesophageal varices, spleen size, portal vein diameter and maximum and mean portal flow velocity measured by duplex-Doppler ultrasonography were taken into account in a binary forward-stepwise multiple logistic regression analysis. RESULTS: Only three variables were present in the final regression equation, maximum portal flow velocity affording the highest correlation with the histological diagnosis of cirrhosis (p = 0.0007), with an overall predictive value of 87.7%. When associated with the bipolar diameter of the spleen (p = 0.0169) and the number of platelets (p = 0.0487), the predictive value rose to 94.7%. If all three parameters were normal, a non-cirrhotic liver disease was most likely (96% probability); if two or three of the parameters were abnormal, liver cirrhosis was almost certain (98% probability); if only one parameter was abnormal, the clinical diagnosis was uncertain. CONCLUSIONS: This study emphasizes the usefulness of duplex Doppler ultrasonography in the non-invasive diagnosis of compensated cirrhosis.

Relevance of reduced portal flow velocity, low platelet count and enlarged spleen diameter in the non-invasive diagnosis of compensated liver cirrhosis / G., Cioni; E., Tincani; P., D'Alimonte; A., Cristani; Ventura, Paolo; G., Abbati; A., Vignoli; R., Romagnoli; E., Ventura. - In: EUROPEAN JOURNAL OF MEDICINE. - ISSN 1165-0478. - STAMPA. - 2:(1993), pp. 408-410.

Relevance of reduced portal flow velocity, low platelet count and enlarged spleen diameter in the non-invasive diagnosis of compensated liver cirrhosis

VENTURA, Paolo;
1993

Abstract

OBJECTIVES: The aim of this prospective study was to identify the combination of parameters best able to predict the diagnosis of compensated cirrhosis. METHODS: One hundred and fourteen patients with suspected chronic compensated liver disease were divided, on the basis of bioptical findings, into two groups: group A, without cirrhosis (n = 58) and group B, with cirrhosis (n = 56). A number of biochemical parameters, the extent of oesophageal varices, spleen size, portal vein diameter and maximum and mean portal flow velocity measured by duplex-Doppler ultrasonography were taken into account in a binary forward-stepwise multiple logistic regression analysis. RESULTS: Only three variables were present in the final regression equation, maximum portal flow velocity affording the highest correlation with the histological diagnosis of cirrhosis (p = 0.0007), with an overall predictive value of 87.7%. When associated with the bipolar diameter of the spleen (p = 0.0169) and the number of platelets (p = 0.0487), the predictive value rose to 94.7%. If all three parameters were normal, a non-cirrhotic liver disease was most likely (96% probability); if two or three of the parameters were abnormal, liver cirrhosis was almost certain (98% probability); if only one parameter was abnormal, the clinical diagnosis was uncertain. CONCLUSIONS: This study emphasizes the usefulness of duplex Doppler ultrasonography in the non-invasive diagnosis of compensated cirrhosis.
1993
2
408
410
Relevance of reduced portal flow velocity, low platelet count and enlarged spleen diameter in the non-invasive diagnosis of compensated liver cirrhosis / G., Cioni; E., Tincani; P., D'Alimonte; A., Cristani; Ventura, Paolo; G., Abbati; A., Vignoli; R., Romagnoli; E., Ventura. - In: EUROPEAN JOURNAL OF MEDICINE. - ISSN 1165-0478. - STAMPA. - 2:(1993), pp. 408-410.
G., Cioni; E., Tincani; P., D'Alimonte; A., Cristani; Ventura, Paolo; G., Abbati; A., Vignoli; R., Romagnoli; E., Ventura
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/617102
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 41
  • ???jsp.display-item.citation.isi??? ND
social impact