Eighteen cirrhotic patients with esophageal varices at risk for bleeding took part in a double-blind study. The variations in PFV induced by either 40 mg of propranolol or 60 mg of sustained-release isosorbide-5-mononitrate on two consecutive days were evaluated with a duplex Doppler device. Both drugs caused a significant decrease in maximum (propranolol, P = 0.002; isosorbide-5-mononitrate, P = 0.021). Four patients responded to propranolol, three to isosorbide-5-mononitrate, and eight to both drugs; three did not show any change. Duplex Doppler sonography may be of use in the selection of the right pharmacologic treatment for the individual patient for the prevention of a bleeding esophageal varix.
Duplex Doppler ultrasonographic comparison of the effects of propranolol and isosorbide-5-mononitrate on portal hemodynamics / E., Tincani; G., Cioni; A., Cristani; P., D'Alimonte; A., Vignoli; G., Abbati; Ventura, Paolo; R., Romagnoli; E., Ventura. - In: JOURNAL OF ULTRASOUND IN MEDICINE. - ISSN 0278-4297. - STAMPA. - 12:(1994), pp. 525-529.