Twenty-five liver cirrhosis patients with endoscopically demonstrated gastro-duodenal mucosal damage (microhemorrhages, erosions, ulcers) were treated with misoprostol (prostaglandin E1) 400 mg/die. Eleven patients (44%) had abdominal pain and diarrhea and stopped treatment. Three months later, a new endoscopy was performed in the 11 patients that completed the study (3 patients were lost at follow up). Mucosal damage was stable in 5 patients (45%) and improved in 6 patients (55%), with complete absence of mucosal lesions in 2 patients (P = 0.027, Wilcoxon Ranks test). No case of worsening was observed and no patient had digestive bleeding during treatment. Digestive bleeding is a common complication of liver cirrhosis, originating in about 50% of cases from gastro-duodenal mucosal damage. Misoprostol suggests itself as a possible alternative therapy to the drugs usually utilized in these lesions (beta-blockers, H2-inhibitors), but individual intolerance is frequent and must be preliminary excluded.

The activity of misoprostol on the gastric and duodenal mucosal damage in patients with liver cirrhosis / G., Abbati; G., Cioni; A., Cristani; G., Rigo; A., Vignoli; Ventura, Paolo; E., Tincani; E., Ventura. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 143:(1993), pp. 315-319.

The activity of misoprostol on the gastric and duodenal mucosal damage in patients with liver cirrhosis

VENTURA, Paolo;
1993

Abstract

Twenty-five liver cirrhosis patients with endoscopically demonstrated gastro-duodenal mucosal damage (microhemorrhages, erosions, ulcers) were treated with misoprostol (prostaglandin E1) 400 mg/die. Eleven patients (44%) had abdominal pain and diarrhea and stopped treatment. Three months later, a new endoscopy was performed in the 11 patients that completed the study (3 patients were lost at follow up). Mucosal damage was stable in 5 patients (45%) and improved in 6 patients (55%), with complete absence of mucosal lesions in 2 patients (P = 0.027, Wilcoxon Ranks test). No case of worsening was observed and no patient had digestive bleeding during treatment. Digestive bleeding is a common complication of liver cirrhosis, originating in about 50% of cases from gastro-duodenal mucosal damage. Misoprostol suggests itself as a possible alternative therapy to the drugs usually utilized in these lesions (beta-blockers, H2-inhibitors), but individual intolerance is frequent and must be preliminary excluded.
1993
143
315
319
The activity of misoprostol on the gastric and duodenal mucosal damage in patients with liver cirrhosis / G., Abbati; G., Cioni; A., Cristani; G., Rigo; A., Vignoli; Ventura, Paolo; E., Tincani; E., Ventura. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 143:(1993), pp. 315-319.
G., Abbati; G., Cioni; A., Cristani; G., Rigo; A., Vignoli; Ventura, Paolo; E., Tincani; E., Ventura
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/617100
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