This trial investigated the activity and toxicity of gemcitabine in previously untreated elderly (> 70 years) patients with advanced (stage IIIB-IV) non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: From January 1997 to July 1998, 46 patients with advanced NSCLC aged over 70 years with a performance status of 0-2 were entered into the study. Gemcitabine 1000 mg/m2 was administered as a 30-min infusion once a week for 3 weeks followed by a week of rest; cycles were repeated every 4 weeks. RESULTS: Forty-four patients were evaluable for response. One complete response and nine partial responses were observed, for an overall response rate of 22.2% (95% C.I.: 11.3-37.5). The median time to disease progression was 5.1 months (95% C.I.: 3.5-6.7), the median duration of response was 6.3 months, and the median overall survival time 6.75 months (95% C.I.: 5.3-8.2). All patients were evaluable for toxicity (184 cycles, median = 3 cycles/patient) and no grade 4 hematologic toxicities were reported. WHO grade 3 leukopenia, neutropenia and anemia occurred in 3.3, 0.5 and 1.1% of cycles, respectively. Grade 3 skin rash occurred in 4.3% of patients. These side effects led to treatment discontinuation in two patients. CONCLUSION: Our data show that gemcitabine is active and well tolerated in patients aged over 70 years with advanced NSCLC.
|Data di pubblicazione:||2000|
|Titolo:||Gemcitabine monotherapy in elderly patients with advanced non-small cell lung cancer. A Multicenter phase II study.|
|Autore/i:||S., Ricci; A., Antonuzzo; L., Galli; C., Tibaldi; M., Bertuccelli; A., Lopes Pegna; S., Petruzzelli; R., Algeri; V., Bonifazi; M. L., Fioretto; C., Orlandini; Conte, Pierfranco|
|Codice identificativo ISI:||WOS:000085189200002|
|Codice identificativo Scopus:||2-s2.0-0033955531|
|Codice identificativo Pubmed:||10688490|
|Citazione:||Gemcitabine monotherapy in elderly patients with advanced non-small cell lung cancer. A Multicenter phase II study / S., Ricci; A., Antonuzzo; L., Galli; C., Tibaldi; M., Bertuccelli; A., Lopes Pegna; S., Petruzzelli; R., Algeri; V., Bonifazi; M. L., Fioretto; C., Orlandini; Conte, Pierfranco. - In: LUNG CANCER. - ISSN 0169-5002. - STAMPA. - 27(2000), pp. 75-80.|
|Tipologia||Articolo su rivista|
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