We investigated the role of 2-[18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the early evaluation of response to chemotherapy in metastatic breast cancer patients. Breast cancer patients who received an epirubicin/paclitaxel--containing regimen as first-line treatment for metastatic disease were included in this study. A PET study was performed within 1 week before the start of treatment, at day 8 after the first course, and at the end of the planned program of chemotherapy. Tumor response was determined clinically and radiographically every 2 courses of treatment. Thirteen patients with metastatic breast cancer who were referred for treatment protocols with gemcitabine/epirubicin/paclitaxel or epirubicin/paclitaxel chemotherapy regimens were included in this study. All metastatic sites were easily visualized on the baseline FDG-PET images, obtained 50 to 60 minutes after tracer injection. Nine patients who completed the planned courses of chemotherapy and the FDG-PET studies were available for analysis. In the six patients who achieved a response to treatment, median glucose standard uptake value (SUV) (semiquantitative analysis) was 7.65 (range, 3.4-12.3) at baseline, 5.7 (range, 2.8-7.6) at day 8 after the first course, and 1.2 (range, 0.99-1.3) at the end of the 6 planned courses of chemotherapy. Three patients who obtained a stable disease as best response had no significant decrease in tumor glucose SUV compared to baseline levels. Qualitative visual analysis in the six responding patients showed a decrease in delineation of tumor mass from background activity soon after the first course, while the nonresponding patients had no significant modification from basal levels. Semiquantitative FDG-PET scanning of metastatic breast cancer sites showed a rapid and significant decrease in tumor glucose metabolism soon after the first course of treatment in patients who achieved a response to first-line chemotherapy. On the contrary, no significant decrease was observed in nonresponding patients.
|Data di pubblicazione:||2000|
|Titolo:||Role of 2-(18F)-fluorodeoxyglucose (FDG) positron emisssion tomography (PET) in the early assessment of response to chemotherapy in metastatic breast cancer patients.|
|Autore/i:||A., Gennari; S., Donati; B., Salvadori; A., Giorgetti; Pa, Salvadori; O., Sorace; G., Puccini; P., Pisani; M., Poli; D., Dani; E., Landucci; G., Mariani; Conte, Pierfranco|
|Codice identificativo Scopus:||2-s2.0-0034236325|
|Codice identificativo Pubmed:||11899654|
|Citazione:||Role of 2-(18F)-fluorodeoxyglucose (FDG) positron emisssion tomography (PET) in the early assessment of response to chemotherapy in metastatic breast cancer patients / A., Gennari; S., Donati; B., Salvadori; A., Giorgetti; Pa, Salvadori; O., Sorace; G., Puccini; P., Pisani; M., Poli; D., Dani; E., Landucci; G., Mariani; Conte, Pierfranco. - In: CLINICAL BREAST CANCER. - ISSN 1526-8209. - STAMPA. - 1(2000), pp. 156-161.|
|Tipologia||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris