Leukotrienes, products of the 5-lipoxygenase pathway of arachidonic acid, are pro-inflammatory mediators with various biological activities, including mechanisms relevant to the pathogenesis of bronchoobturation in bronchial asthma. This article reviews the evidence on their role in the pathophysiology of asthma as well as on the efficacy of recently developed antileukotriene agents.
Role of leukotrienes in asthma pathogenesis / Fabbri, Leonardo; G., Caramori; Beghe', Bianca; A., Ciaccia. - In: MONALDI ARCHIVES FOR CHEST DISEASE. - ISSN 1122-0643. - STAMPA. - 51:(1996), pp. 548-555.
Role of leukotrienes in asthma pathogenesis.
FABBRI, Leonardo;BEGHE', Bianca;
1996
Abstract
Leukotrienes, products of the 5-lipoxygenase pathway of arachidonic acid, are pro-inflammatory mediators with various biological activities, including mechanisms relevant to the pathogenesis of bronchoobturation in bronchial asthma. This article reviews the evidence on their role in the pathophysiology of asthma as well as on the efficacy of recently developed antileukotriene agents.
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