Extracts from pods and leaves of carob (Ceratonia siliqua L.) were tested for their ability to inhibit cell proliferation of mouse hepatocellular carcinoma cell line (T1). The two extracts showed a marked alteration of T1 cell proliferation in a dose-related fashion reaching the maximal effect at 1 mg/ml. Moreover, we demonstrated that leaf and pod extracts were able to induce apoptosis in T1 cell lines after 24-h treatment mediating a direct activation of the caspase 3 pathway. HPLC analysis revealed the presence of gallic acid, epigallocatechin-3-gallate and (-) epi catechin - 3 -gallate in pod and leaf extracts, compounds well known to exert antiproliferative effects. Their concentration reached 6.28 mg/g in carob leaves and 1.36 mg/g in carob pods extract. The discovery that carob pod and leaf extracts contained antiproliferative agents could be of practical importance in the development of functional foods and/or chemopreventive drugs.

Antiproliferative effects of Ceratonia siliqua L. on mouse hepatocellular carcinoma cell line / Corsi, Lorenzo; Avallone, Rossella; F., Cosenza; F., Farina; Baraldi, Claudia; Baraldi, Mario. - In: FITOTERAPIA. - ISSN 1971-551X. - STAMPA. - 73:(2002), pp. 674-684.

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