Human herpesvirus-8 (HHV-8) genome encodes for genes homologous to human cellular genes such as interleukin-6 (IL-6), Cyclin-D, BCL-5, and IL-8 receptor (G-protein-coupled receptor [GCR]), We used reverse transcriptase-polymerase chain reaction to study the expression of these viral genes in lymphoproliferative disorders associated with HHV-8 infection, None of these genes was expressed in 1 case of benign, localized Castleman´s disease (CD), and only viral IL-6 and viral Cyclin-D were transcribed in 2 cases of benign lymphadenopathies with giant germinal center hyperplasia and increased vascularity. In contrast, all 4 genes were transcribed in 1 case of multicentric CD of plasma cell type with aggressive clinical course and in 1 primary effusion lymphoma cell line. Our study provides the evidence that various HHV-8 genes, homologous to cellular genes involved in control of proliferation and apoptosis, may be differently expressed in different lymphoid disorders in vivo.

Expression of cell-homologous genes of human herpesvirus-8 in human immunodeficiency virus-negative lymphoproliferative diseases / Luppi, Mario; Barozzi, Patrizia; Maiorana, Antonino; R., Trovato; Marasca, Roberto; M., Morselli; K., Cagossi; Torelli, Giuseppe. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 94:8(1999), pp. 2931-2933.

Expression of cell-homologous genes of human herpesvirus-8 in human immunodeficiency virus-negative lymphoproliferative diseases

LUPPI, Mario;BAROZZI, Patrizia;MAIORANA, Antonino;MARASCA, Roberto;TORELLI, Giuseppe
1999

Abstract

Human herpesvirus-8 (HHV-8) genome encodes for genes homologous to human cellular genes such as interleukin-6 (IL-6), Cyclin-D, BCL-5, and IL-8 receptor (G-protein-coupled receptor [GCR]), We used reverse transcriptase-polymerase chain reaction to study the expression of these viral genes in lymphoproliferative disorders associated with HHV-8 infection, None of these genes was expressed in 1 case of benign, localized Castleman´s disease (CD), and only viral IL-6 and viral Cyclin-D were transcribed in 2 cases of benign lymphadenopathies with giant germinal center hyperplasia and increased vascularity. In contrast, all 4 genes were transcribed in 1 case of multicentric CD of plasma cell type with aggressive clinical course and in 1 primary effusion lymphoma cell line. Our study provides the evidence that various HHV-8 genes, homologous to cellular genes involved in control of proliferation and apoptosis, may be differently expressed in different lymphoid disorders in vivo.
94
8
2931
2933
Expression of cell-homologous genes of human herpesvirus-8 in human immunodeficiency virus-negative lymphoproliferative diseases / Luppi, Mario; Barozzi, Patrizia; Maiorana, Antonino; R., Trovato; Marasca, Roberto; M., Morselli; K., Cagossi; Torelli, Giuseppe. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 94:8(1999), pp. 2931-2933.
Luppi, Mario; Barozzi, Patrizia; Maiorana, Antonino; R., Trovato; Marasca, Roberto; M., Morselli; K., Cagossi; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/613306
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