The marine dinoflagellate Gambierdiscus toxicus produces highly lipophilic, polycyclic ether toxins that cause a seafood poisoning called ciguatera. Ciguatoxins (CTXs) and gambierol represent the two major causative agents of ciguatera intoxication, which include taste alterations (dysgeusiae). However, information on the mode of action of ciguatera toxins in taste cells is scarce. Here, we have studied the effect of synthetic CTX3C (a CTX congener) on mouse taste cells. By using the patch-clamp technique to monitor membrane ion currents, we found that CTX3C markedly affected the operation of voltage-gated Na+ channels but was ineffective on voltage-gated K+ channels. This result was the exact opposite of what we obtained earlier with gambierol, which inhibits K+ channels but not Na+ channels. Thus, CTXs and gambierol affect with high potency the operation of separate classes of voltage-gated ion channels in taste cells. Our data suggest that taste disturbances reported in ciguatera poisoning might be due to the ability of ciguatera toxins to interfere with ion channels in taste buds.
|Data di pubblicazione:||2006|
|Titolo:||Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells|
|Autore/i:||V. Ghiaroni; G. Scalera; H. Fuwa; M. Inoue; M. Sasaki; K. Miyazaki; GP Rossini; M. Hirama; T. Yasumoto; A. Bigiani|
|Codice identificativo ISI:||WOS:000240680100009|
|Codice identificativo Scopus:||2-s2.0-33749551080|
|Citazione:||Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells / V. Ghiaroni; G. Scalera; H. Fuwa; M. Inoue; M. Sasaki; K. Miyazaki; GP Rossini; M. Hirama; T. Yasumoto; A. Bigiani. - In: CHEMICAL SENSES. - ISSN 0379-864X. - STAMPA. - 31(2006), pp. 673-680.|
|Tipologia||Articolo su rivista|
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