Palatability and variety of foods are major reasons for “hedonic” eating, and hence for overeating and obesity. Palatable food and drugs of abuse share a common reward mechanism, and compounds that block the reinforcing effect of drugs of abuse preferentially suppress the intake of palatable foods. This research was aimed at studying the inﬂuence of the gamma-hydroxybutyrate analogue N-(4-triﬂuoromethylbenzyl)-4¬methoxybutanamide (GET73) – that inhibits alcohol consumption – on consumption and reinforcing effect of palatable food. Adult male rats were used. For place preference conditioning, sweetened corn ﬂakes were used as the reinforcer, and GET73 (50, 100 and 200 mg kg−1) or vehicle were orally (p.o.) administered either 30 min before each training session and the test session, or only before the test session. To study the inﬂuence on con¬sumption, GET73 was given p.o. at the same doses once daily for 12 days to rats given free access to both palatable and varied food (cafeteria diet) or to standard chow. Both acquisition and expression of palatable food-induced conditioned place preference were inhibited by GET73, either adminis¬tered throughout the conditioning period or only before the test session. GET73 reduced also the consumption of cafeteria food, while that of standard chow was increased. At these doses, GET73 had no detrimental effect on open-ﬁeld behaviour. GET73 seems to speciﬁcally attenuate the gratiﬁcation produced by varied and palatable food, without affecting the consumption of not particularly palatable chow. Since, overweight and obesity are mostly due to the overeating of palatable and varied foods, drugs like GET73 could represent a somewhat ideal and rational approach to obesity treatment.
Attenzione! Scheda prodotto non ancora validata dall'Ateneo
|Anno di pubblicazione:||2007|
|Titolo:||Preference for palatable food is reduced by the gamma-hydroxybutyrate analogue GET73, in rats|
|Autori:||Ottani A; Leone S; Vergara Garcia FB; Tacchi R; Loche A; Bertolini A.|
|Appare nelle tipologie:||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris