Lipospheres loaded with sunscreen BMDBM were prepared and evaluated for skin permeation both in vivo, by tape stripping method, and in vitro, by a flow-through diffusion chamber. The results were found to be predicted by an in vitro methodology involving the diffusion of BMDBM through a lipophilized syntetic membrane into a hydrophilic receptor phase, simulating the viable epidermis better than an ethanolic receptor phase.
In vivo and in vitro skin permeation of Butyl Methoxydibenzoylmethane from lipospheres / Iannuccelli, Valentina; Coppi, Gilberto; Sergi, Santo; M., Mezzena; S., Scalia. - In: SKIN PHARMACOLOGY AND PHYSIOLOGY. - ISSN 1660-5527. - STAMPA. - 21:1(2008), pp. 30-38. [10.1159/000109656]
In vivo and in vitro skin permeation of Butyl Methoxydibenzoylmethane from lipospheres
IANNUCCELLI, Valentina;COPPI, Gilberto;SERGI, Santo;
2008
Abstract
Lipospheres loaded with sunscreen BMDBM were prepared and evaluated for skin permeation both in vivo, by tape stripping method, and in vitro, by a flow-through diffusion chamber. The results were found to be predicted by an in vitro methodology involving the diffusion of BMDBM through a lipophilized syntetic membrane into a hydrophilic receptor phase, simulating the viable epidermis better than an ethanolic receptor phase.
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