Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary disease leading to death within a few years of diagnosis despite medical therapy. On the basis of methodologies of the Cochrane collaboration, this overview discusses the evidence for IPF therapy. Good-quality studies on oral corticosteroids, the most common medical therapy in use for IPF, are lacking. A few small studies have been carried out on the efficacy of many non-steroid immunosuppressive agents, and the results have been generally disappointing. The most extensively studied medical therapy, gamma interferon, showed a significant effect in a small randomized study, but its efficacy was not confirmed in a larger randomized-controlled trial. The long-awaited good news for patients affected by this deadly disease, and for their physicians, could come in the near future from large randomized-controlled trials with gamma interferon or other immunomodulatory agents.
Corticosteroid and immunomodulatory agents in idiopathic pulmonary fibrosis / F., Luppi; Cerri, Stefania; Beghe', Bianca; Fabbri, Leonardo; Richeldi, Luca. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - STAMPA. - 98:(2004), pp. 1035-1044.
Data di pubblicazione: | 2004 | |
Titolo: | Corticosteroid and immunomodulatory agents in idiopathic pulmonary fibrosis | |
Autore/i: | F., Luppi; Cerri, Stefania; Beghe', Bianca; Fabbri, Leonardo; Richeldi, Luca | |
Autore/i UNIMORE: | ||
Rivista: | ||
Volume: | 98 | |
Pagina iniziale: | 1035 | |
Pagina finale: | 1044 | |
Codice identificativo ISI: | WOS:000224709700001 | |
Codice identificativo Scopus: | 2-s2.0-4844231301 | |
Codice identificativo Pubmed: | 15526803 | |
Citazione: | Corticosteroid and immunomodulatory agents in idiopathic pulmonary fibrosis / F., Luppi; Cerri, Stefania; Beghe', Bianca; Fabbri, Leonardo; Richeldi, Luca. - In: RESPIRATORY MEDICINE. - ISSN 0954-6111. - STAMPA. - 98:(2004), pp. 1035-1044. | |
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