BACKGROUND: The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD. METHODS: The expression of TGF-beta and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function. RESULTS: The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50). CONCLUSIONS: In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion.

Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD / S., Baraldo; E., Bazzan; G., Turato; F., Calabrese; Beghe', Bianca; A., Papi; P., Maestrelli; Fabbri, Leonardo; R., Zuin; M., Saetta. - In: THORAX. - ISSN 0040-6376. - STAMPA. - 60:(2005), pp. 998-1002.

Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD

BEGHE', Bianca;FABBRI, Leonardo;
2005

Abstract

BACKGROUND: The role of transforming growth factor-beta1 (TGF-beta1) in chronic obstructive pulmonary disease is still controversial, but it has been proposed that it may protect from mucus hypersecretion since it is able to downregulate mucin production. A study was undertaken to investigate the expression of TGF-beta1 and its type II receptor (TGF-beta RII) in the bronchial glands of smokers with COPD. METHODS: The expression of TGF-beta and TGF-beta RII were examined immunohistochemically in the bronchial glands of 24 smokers undergoing lung resection for solitary peripheral nodules: 12 with airflow limitation (smokers with COPD) and 12 with normal lung function. RESULTS: The expression of TGF-beta1 in bronchial glands was similar in the two groups of subjects while that of TGF-beta RII was lower in smokers with COPD than in smokers with normal lung function (p=0.004). TGF-beta RII expression was inversely correlated with the values of Reid's index, a measure of gland size (p=0.02, r=-0.50). CONCLUSIONS: In the bronchial glands of smokers with COPD there is decreased expression of TGF-beta RII which is associated with bronchial gland enlargement. These findings support the view that the absence of TGF-beta signalling may induce structural changes in the bronchial glands which, in turn, may promote mucus hypersecretion.
60
998
1002
Decreased expression of TGF-beta type II receptor in bronchial glands of smokers with COPD / S., Baraldo; E., Bazzan; G., Turato; F., Calabrese; Beghe', Bianca; A., Papi; P., Maestrelli; Fabbri, Leonardo; R., Zuin; M., Saetta. - In: THORAX. - ISSN 0040-6376. - STAMPA. - 60:(2005), pp. 998-1002.
S., Baraldo; E., Bazzan; G., Turato; F., Calabrese; Beghe', Bianca; A., Papi; P., Maestrelli; Fabbri, Leonardo; R., Zuin; M., Saetta
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/613038
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