EnglishThe triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule, which plays an important role in myeloid cell-activated inflammatory responses. TREM-1 is expressed on blood neutrophils and monocytes, and also on alveolar macrophages, thus suggesting a potential role in lung inflammatory responses against infections. To investigate the differential expression of TREM-1 in lung infections, its levels were assessed in bronchoalveolar lavage specimens from patients with community-acquired pneumonia or tuberculosis. TREM-1 was also investigated in patients with interstitial lung diseases, as a model of noninfectious inflammatory disease of the lung. TREM-1 expression was significantly increased in lung neutrophils; and in lung macrophages of patients with pneumonia (n=7; 387.9+/-61.4 and 660.5+/-18.3, respectively) compared with patients with pulmonary tuberculosis (n=7; 59.2+/-13.1 and 80.6+/-291.2) and patients with interstitial lung diseases (n=10; 91.8+/-23.3 and 123.9+/-22.8). In contrast, TREM-1 expression on peripheral blood neutrophils was no different among the three groups. In conclusion, these data suggest that triggering receptor expressed on myeloid cells-1 is selectively expressed in the lungs of patients with pneumonia caused by extracellular bacteria and not in patients with tuberculosis, providing a potential marker for differential diagnosis.
| Data di pubblicazione: | 2004 |
| Titolo: | Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections |
| Autore/i: | L. Richeldi; M. Mariani; M. Losi; F. Maselli; L. Corbetta; C. Buonsanti; M. Colonna; F. Sinigaglia; P. Panina-Bordignon; L. M. Fabbri |
| Autore/i UNIMORE: | |
| Rivista: | |
| Volume: | 24 |
| Pagina iniziale: | 247 |
| Pagina finale: | 250 |
| Codice identificativo ISI: | WOS:000223034600011 |
| Codice identificativo Scopus: | 2-s2.0-4344604292 |
| Codice identificativo Pubmed: | 15332392 |
| Citazione: | Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections / L. Richeldi; M. Mariani; M. Losi; F. Maselli; L. Corbetta; C. Buonsanti; M. Colonna; F. Sinigaglia; P. Panina-Bordignon; L. M. Fabbri. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - STAMPA. - 24(2004), pp. 247-250. |
| Tipologia | Articolo su rivista |
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