The peripheral benzodiazepine receptor system triggers intracellular metabolic events and has been associated with cell proliferation. Its endogenous ligand, the diazepam binding inhibitor, contributes to steroidogenesis by promoting cholesterol delivery to the inner mitochondrial membrane. The present study was undertaken to verify whether this system is altered in tumors sited in the liver. Peripheral benzodiazepine receptors and diazepam binding inhibitor were studied using immunocytochemistry and in situ hybridization in 9 human tumors sited in the liver, in liver hyperplasia, cirrhotic nodular regeneration, intestinal adenocarcinoma and in surrounding non-tumoral tissue. Immunocytochemical staining and in situ hybridization demonstrated that peripheral benzodiazepine receptors and diazepam binding inhibitor were more prominently expressed in neoplastic cells than in non-tumoral tissue. They were present in the same cells, suggesting that diazepam binding inhibitor may act in an intracrine manner in these cells. Higher peripheral benzodiazepine receptors and diazepam binding inhibitor expression in tumor cells suggest an implication of this system in the metabolism of neoplastic cells. Furthermore the evaluation of peripheral benzodiazepine receptor and diazepam binding inhibitor expression might be useful in evaluating malignancy and in diagnostic approaches of tumors in liver tissue.

Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver / I., Venturini; H., Alho; I., Podkletnova; Corsi, Lorenzo; E., Rybnikova; R., Pellicci; Baraldi, Mario; M., Pelto Huikko; P., Helen; Zeneroli, Maria Luisa. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 65:(1999), pp. 2223-2231.

Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver

CORSI, Lorenzo;BARALDI, Mario;ZENEROLI, Maria Luisa
1999

Abstract

The peripheral benzodiazepine receptor system triggers intracellular metabolic events and has been associated with cell proliferation. Its endogenous ligand, the diazepam binding inhibitor, contributes to steroidogenesis by promoting cholesterol delivery to the inner mitochondrial membrane. The present study was undertaken to verify whether this system is altered in tumors sited in the liver. Peripheral benzodiazepine receptors and diazepam binding inhibitor were studied using immunocytochemistry and in situ hybridization in 9 human tumors sited in the liver, in liver hyperplasia, cirrhotic nodular regeneration, intestinal adenocarcinoma and in surrounding non-tumoral tissue. Immunocytochemical staining and in situ hybridization demonstrated that peripheral benzodiazepine receptors and diazepam binding inhibitor were more prominently expressed in neoplastic cells than in non-tumoral tissue. They were present in the same cells, suggesting that diazepam binding inhibitor may act in an intracrine manner in these cells. Higher peripheral benzodiazepine receptors and diazepam binding inhibitor expression in tumor cells suggest an implication of this system in the metabolism of neoplastic cells. Furthermore the evaluation of peripheral benzodiazepine receptor and diazepam binding inhibitor expression might be useful in evaluating malignancy and in diagnostic approaches of tumors in liver tissue.
65
2223
2231
Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver / I., Venturini; H., Alho; I., Podkletnova; Corsi, Lorenzo; E., Rybnikova; R., Pellicci; Baraldi, Mario; M., Pelto Huikko; P., Helen; Zeneroli, Maria Luisa. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 65:(1999), pp. 2223-2231.
I., Venturini; H., Alho; I., Podkletnova; Corsi, Lorenzo; E., Rybnikova; R., Pellicci; Baraldi, Mario; M., Pelto Huikko; P., Helen; Zeneroli, Maria Luisa
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/612763
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