This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.
Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line / Hakim, G; Fiorentini, D; Maraldi, Tullia; Landi, L.. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - ELETTRONICO. - 53:4(2004), pp. 135-140.
Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line
MARALDI, Tullia;
2004
Abstract
This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H202 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested.
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