The dystroglycan (DG) complex is a transmembrane glycoprotein that forms a continuous link from the extracellular matrix to the actin cytoskeleton. Deregulated expression of DG has been reported in a variety of human malignancies and related to tumor aggressiveness. In this study expression of the DG subunit was evaluated by immunostaining in a series of renal epithelial cancers and its relation with traditional prognostic indicators and with the clinical outcome of the patients was evaluated. alphaDG expression was undetectable in a significant fraction of tumors (54%). In renal cell carcinomas (RCC) loss of alpha-DG staining correlated with higher tumor grade (p = 0.02) but not with tumor stage nor tumor size. In clear cell RCC patients loss of alphaDG staining correlated with an increased risk of recurrence (p = 0.002 by log-rank test) and death (p = 0.004) also when patients with lower grade or stage tumors were analyzed separately. In a multivariate analysis loss of DG staining confirmed to be and independent predictor of shorter disease-free (p = 0.001; RR = 4.9) and overall (p = 0.009; RR = 4.9) survival stronger than tumor grade and size. These findings demonstrate that loss of alphaDG expression, which correspond to loss of a functional DG complex, is a frequent event in human renal tumorigenesis and is an independent predictor of early recurrence and death for patients with clear cell RCC.

Expression of dystroglycan correlates with tumor grade and predicts survival in renal cell carcinoma / Sgambato, A; Camerini, A; Amoroso, D; Genovese, G; De Luca, F; Cecchi, M; Migaldi, Mario; Rettino, A; Valsuani, C; Tartarelli, G; Donati, S; Siclari, O; Rossi, G; Cittadini, A.. - In: CANCER BIOLOGY & THERAPY. - ISSN 1538-4047. - STAMPA. - 6:(2007), pp. 1840-1846.

Expression of dystroglycan correlates with tumor grade and predicts survival in renal cell carcinoma.

MIGALDI, Mario;
2007

Abstract

The dystroglycan (DG) complex is a transmembrane glycoprotein that forms a continuous link from the extracellular matrix to the actin cytoskeleton. Deregulated expression of DG has been reported in a variety of human malignancies and related to tumor aggressiveness. In this study expression of the DG subunit was evaluated by immunostaining in a series of renal epithelial cancers and its relation with traditional prognostic indicators and with the clinical outcome of the patients was evaluated. alphaDG expression was undetectable in a significant fraction of tumors (54%). In renal cell carcinomas (RCC) loss of alpha-DG staining correlated with higher tumor grade (p = 0.02) but not with tumor stage nor tumor size. In clear cell RCC patients loss of alphaDG staining correlated with an increased risk of recurrence (p = 0.002 by log-rank test) and death (p = 0.004) also when patients with lower grade or stage tumors were analyzed separately. In a multivariate analysis loss of DG staining confirmed to be and independent predictor of shorter disease-free (p = 0.001; RR = 4.9) and overall (p = 0.009; RR = 4.9) survival stronger than tumor grade and size. These findings demonstrate that loss of alphaDG expression, which correspond to loss of a functional DG complex, is a frequent event in human renal tumorigenesis and is an independent predictor of early recurrence and death for patients with clear cell RCC.
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Expression of dystroglycan correlates with tumor grade and predicts survival in renal cell carcinoma / Sgambato, A; Camerini, A; Amoroso, D; Genovese, G; De Luca, F; Cecchi, M; Migaldi, Mario; Rettino, A; Valsuani, C; Tartarelli, G; Donati, S; Siclari, O; Rossi, G; Cittadini, A.. - In: CANCER BIOLOGY & THERAPY. - ISSN 1538-4047. - STAMPA. - 6:(2007), pp. 1840-1846.
Sgambato, A; Camerini, A; Amoroso, D; Genovese, G; De Luca, F; Cecchi, M; Migaldi, Mario; Rettino, A; Valsuani, C; Tartarelli, G; Donati, S; Siclari, O; Rossi, G; Cittadini, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/612622
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